INFORMATION SHEET ON PLEGINE, TEPANIL, AND OBENIX
Plegine (phendimetrazine) is an anorectic (appetite suppressant) medication which has been available for limited short-
term use for some time. Recent research has demonstrated its usefulness for periods of up to four years or longer in
some patients. It is, of course, a prescription medication and is classified by the government as a controlled substance.
This acknowledges that it has some abuse potential; there are restrictions on its use due to the requirements of good
medical practice as wel as the law. For this reason, we must see patients on this medication every four weeks without
exception and it can only be used after an initial complete physical and a yearly complete physical thereafter. Two other
similar appetite suppressants are Tepanil (diethylpropion) and Obenix (phentermine). Al three of these medications are
members of the same therapeutic class but they have different side effect profiles and durations of action. Because of
differences in individual chemistry and concomitant medical conditions one medication may be more effective or
otherwise preferable. It is sometimes appropriate to use more than one appetite suppressant at a time in the same
It is very important that we know of any other medications or herbal preparations you are on, either prescription or non-
prescription as there is always a chance of drug interactions. Also, it is very important that you take the vitamins and
minerals which we prescribe because it is impossible to be on a balanced diet with fewer than 1100 calories without some
As with any medication, side effects can occur. These are usual y mild and transient. The most common side effects are
nervousness and insomnia. If these occur, you should certainly discontinue the medication until you talk to me. Some
people notice a dry mouth sensation when they first start the medication.
The reason we dispense appetite suppressants in this office is due to their lack of availability in many local pharmacies.
Many of our patients come from long distances to see us and have had problems with unusual y high costs or lack of
availability of the medication locally. We ordinarily dispense those oral medications which we have available in the office
Meridia (sibutramine) is another appetite suppressant medication which we occasional y use; it is not dispensed in this
office but requires that a prescription be fil ed at additional patient expense. The fat blocker Xenical (orlistat) is not
dispensed in this office but is sometimes used for patients on a low-fat diet; patients who use this must bear the
pharmacy expense, as is the case with medications such as Topamax and 5-HTP/Carbidopa. Over-the-counter
preparations which contain ephedrine (e.g., “Chinese herbs”) are variable in their composition and should not be used
Due to some recent reports of possible interactions between general anesthesia and appetite suppressants they should be
discontinued two weeks before elective procedures in which the patient wil be put to sleep.
In addition to the findings of our physical examination and laboratory work, you should not be on these medications if
you have glaucoma, advanced arteriosclerosis, or an allergy to stimulant medications. These medications should also not
be used if you have any history of drug abuse.
Your signature below acknowledges that you have read and understood these instructions. Please note that, although
these medications are not amphetamines, they can cause urine tests for amphetamines to be positive. For this reason, if
your employment requires drug testing, please note the medications you are on.
IF YOU ARE A WOMAN OF REPRODUCTIVE AGE, IT IS VERY IMPORTANT THAT YOU USE AN EFFECTIVE FORM OF BIRTH CONTROL WHILE ON MEDICATIONS OR ON A STRICT DIET. IT IS NOT KNOWN IF RIGID DIETING OR ANY OF THESE MEDICATIONS CAN HAVE AN ADVERSE EFFECT ON PREGNANCY.
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