Tadalafil entfaltet seine Wirkung über eine selektive Hemmung der PDE5, wodurch die Konzentration von cGMP im glatten Muskelgewebe stabil bleibt. Diese biochemische Modulation resultiert in einer langanhaltenden Relaxation der Gefäßwände. Der Wirkstoff wird nach oraler Einnahme effizient resorbiert, mit einer Bioverfügbarkeit von rund 80 %. Seine Halbwertszeit von bis zu 36 Stunden ist innerhalb dieser Substanzklasse außergewöhnlich. Abgebaut wird er in der Leber, hauptsächlich durch CYP3A4, mit anschließender biliärer Exkretion. Typische unerwünschte Wirkungen entstehen durch eine verstärkte Vasodilatation, etwa Kopfschmerzen oder Flush. Pharmakologisch wird cialis generika vor allem durch die verlängerte Wirkungsdauer charakterisiert.

Microsoft word - scheda rochira.doc

VINCENZO ROCHIRA
Ricercatore Universitario Confermato SSD MED/50 Endocrinologia, Centro Nalin , Largo del Pozzo 71 Modena IGIENE DENTALE

Breve Curriculum Vitae
Laurea in Medicina e Chirurgia nel 1994 presso l’Università di Modena, specializzazione in Endocrinologia e Malattie del Ricambio presso l'Universita' di Modena nel 1999, Dottorato di Ricerca in Scienze Endocrino-Metaboliche nel 2004. Ricercatore Universitario presso la Facoltà Medicina e Chirurgia dell'Universita' di Modena Pubblicazioni più recenti
Autore di circa 40 pubblicazioni in extenso su riviste internazionali indicizzate e circa 200
pubblicazioni compresi gli atti di congressi e l’attività editoriale e trattatistica.
1. Lo Re V 3rd, Guaraldi G, Leonard MB, Localio AR, Lin J, Orlando G, Zirilli L, Rochira V, Kostman JR, Tebas P. Viral hepatitis is associated with reduced bone mineral density in HIV-infected women but not men. AIDS. 2009 Sep 23. [Epub ahead of print] 2. Rochira V, Carani C. Aromatase deficiency in men: a clinical perspective. Nat Rev 3. Zirilli L, Maffei L, Meunier PJ, Chavassieux P, Carani C, Rochira V. The effects of long- term raloxifene and estradiol treatments on bone in a patient with congenital aromatase deficiency. Bone. 2009 45:827-32. 4. Luzi K, Guaraldi G, Murri R, De Paola M, Orlando G, Squillace N, Esposito R, Rochira V, Zirilli L, Martinez E. Body image is a major determinant of sexual dysfunction in stable HIV-infected women. Antivir Ther. 2009;14: 85-92. 5. Zirilli L, Benatti P, Romano S, Roncucci L, Rossi G, Diazzi C, Carani C, Ponz De Leon M, Rochira V. Differentiated thyroid carcinoma (DTC) in a young woman with Peutz-Jeghers syndrome: are these two conditions associated? Exp Clin Endocrinol Diabetes. 2009 117:234-9. 6. Rochira V, Zirilli L, Madeo B, Maffei L, Carani C. Testosterone action on erythropoiesis does not require its aromatization to estrogen: Insights from the testosterone and estrogen treatment of two aromatase-deficient men. J Steroid Biochem Mol Biol. 2009 113:189-94. 7. Zirilli L, Orlando G, Diazzi C, Squillace N, Carani C, Guaraldi G, Rochira V. Hypopituitarism and HIV-infection: a new comorbidity in the HAART era? J Endocrinol Invest. 2008 31:33-8. 8. Salmaggi A, Zirilli L, Pantaleoni C, De Joanna G, Del Sorbo F, Koehler K, Krumbholz M, Huebner A, Rochira V. Late-onset triple A syndrome: a risk of overlooked or delayed diagnosis and management. Horm Res. 2008;70:364-72. 9. Balestrieri A, Zirilli L, Madeo B, Pignatti E, Rossi G, Carani C, Rochira V. 21-hydroxylase deficiency and klinefelter syndrome in an adult man: striking a balance between androgen excess and insufficiency. J Androl. 2008 29:605-9. 10. Lanfranco F, Zirilli L, Baldi M, Pignatti E, Corneli G, Ghigo E, Aimaretti G, Carani C, Rochira V. A novel mutation in the human aromatase gene: insights on the relationship among serum estradiol, longitudinal growth and bone mineral density in an adult man under estrogen replacement treatment. Bone. 2008 Sep;43(3):628-35. 11. Zirilli L, Rochira V, Diazzi C, Caffagni G, Carani C. Human models of aromatase deficiency. J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):212-8. 12. Madeo B, Bettica P, Milleri S, Balestrieri A, Granata AR, Carani C, Rochira V. The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double-dummy, parallel group study. J Sex Med. 2008 Oct;5(10):2431-41.

Source: http://cdm.unimore.it/home/medicina/SchedeAteneo/Scheda.Rochira.Vincenzo.pdf