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From the Department of EmergencyMedicine, Traumatology, andRehabilitation, Hartford Hospital,
Hartford, Connecticut, and theDepartment of Physical Medicine andRehabilitation, Hospital for SpecialCare, New Britain, Connecticut.
Data System for MedicalRehabilitation, a division of UB
Intervention in Brain Injury Agitation
reprints should be addressed toDennis Rosati, MD, Hospital for
Rosati DL: Early polyneuropharmacologic intervention in brain injury
agitation. Am J Phys Med Rehabil
To evaluate clinical outcomes observed in the treatment of
0894-9115/02/8102-0090/0American Journal of Physical
posttraumatic brain injury agitation with multiple medications.
Medicine & Rehabilitation
Copyright 2002 by Lippincott
Longitudinal evaluation of effect of treatment intervention on
patients admitted to a level 1 trauma center with traumatic brain injury.
Eleven adult patients referred for physiatry consultation to manageposttraumatic brain injury agitation were treated with a combination ofmedications and other agents (antipsychotics and sedatives) werediscontinued. The Rancho Los Amigos scale was rated on initialconsultation and follow-up, ranging from 1 to 3 wk.
All 11 patients demonstrated an average improvement of
three Rancho Los Amigos levels within an average treatment durationof 10 days. Simultaneously, 9 of 11 patients were discontinued fromtreatment and prescribed antipsychotic and sedative agents.
The findings suggest that administration of multiple
neuropharmacologic agents used early in the treatment of posttrau-matic brain injury agitation may be an effective therapeutic interventionin which behavioral and, possibly, cognitive benefits occur. These re-sults were noted as patients were discontinued from other agents morecommonly employed in the acute care setting for the treatment ofposttraumatic brain injury agitation. Further research is needed to de-termine the most effective medication combinations and the best timeto initiate treatment.
Am. J. Phys. Med. Rehabil.
● Vol. 81, No. 2
Nine of 11 patients
specialists concurred in their ratings.
The setting was a large 650-
RESULTS AND ANALYSIS
of “early” in describing this interven-
All 11 subjects were male
A total of 11 patients with
sultation to evaluate and manage PTA.
DOA/DOC, date of admission/date of consult; RLA (I), Ranchos Los Amigos initial level; MEDS PX, medications prescribed;
DOF, date of followup; DODC, date of discharge; RLA (D/C), Ranchos Los Amigos followup level; CT, computed tomography;MVA, motor vehicle accident.
tal, five of ten patients had their Ativan
Am. J. Phys. Med. Rehabil.
● Vol. 81, No. 2
brain injured patient. Part 1: Definitions,
differential diagnosis and assessment.
Arch Phys Med Rehabil
interact to affect rate of recovery after
motor cortex surgery. Science
and treatment of agitation following trau-
Brain Injury Special Interest Group of the
and Rehabilitation. Arch Phys Med Reha-
ment of acute and chronic behavioral dis-
orders. Phys Med Rehabil Clin North Am
brain injured patient. Part 2: Pathophys-iology and treatment. Arch Phys Med Re-
management of traumatic brain injury.
Phys Med Rehabil Clin North Am
Curriculum Vitae di Delia Romanò Nata il 20 Dicembre 1970 a Milano. Studio: corso Venezia 2, 20121 Milano Tel. e Fax: 02 78.16.57 e-mail: Istruzione e incarichi professionali Maturità Classica presso l’Istituto Suore Marcelline di Milano. Laurea in Medicina e Chirurgia presso l’Università degli Studi di Milano. 1996-2000 Diploma di Specializzazione in Ortopedia e Traumatolog
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