metabolize drugs pdf

Tadalafil entfaltet seine Wirkung über eine selektive Hemmung der PDE5, wodurch die Konzentration von cGMP im glatten Muskelgewebe stabil bleibt. Diese biochemische Modulation resultiert in einer langanhaltenden Relaxation der Gefäßwände. Der Wirkstoff wird nach oraler Einnahme effizient resorbiert, mit einer Bioverfügbarkeit von rund 80 %. Seine Halbwertszeit von bis zu 36 Stunden ist innerhalb dieser Substanzklasse außergewöhnlich. Abgebaut wird er in der Leber, hauptsächlich durch CYP3A4, mit anschließender biliärer Exkretion. Typische unerwünschte Wirkungen entstehen durch eine verstärkte Vasodilatation, etwa Kopfschmerzen oder Flush. Pharmakologisch wird cialis generika vor allem durch die verlängerte Wirkungsdauer charakterisiert.

Microsoft word - 001ho07992 mgd.doc

100% Registered Holstein Ancestry (RHA-NA)
TPI 1HO07992 PALMER
WELCOME OMAN PALMER CRI-ET +1846M 05/26/2004 MALE
USA 61376366 100%RHA-NA TV TL GENESIS COOPERATIVE HERD
100 MBC DR BOX 469
MACE YIELD EVALUATION SHAWANO, WI 54166
PTA +927M +48F +51P 79%R 8/2009 715/526-2141
PTA +551NM +.05%F +.09%P 0%US
PTA +3.7PL 2.85SCS +1.6DPR
MACE TYPE EVALUATION
PTA +1.22T +1.73UDC +1.89FLC 69%R 8/2009 GTPI
HA-HO CUBBY MANFRED-ET +1428G
USA 2183007 100%RHA-NA TV TL
5-07 82 +GVV GM 8/03 12/07/1991
PTA +1265M +40F +39P 99%R 8/2009
PTA +381NM -.02%F +.01%P 44%US
PTA +4.7PL 3.40SCS +2.0DPR 7%DCE
PTA -.85T -1.12UDC +.33FLC 99%R 8/2009
GTPI
MEIER-MEADOWS EL JEZEBEL-ET +1596G
USA 15459080 100%RHA-NA CV BL
5-02 92 EVEVE GMD DOM 06/30/1994
PTA +238M +32F +30P 96%R 8/2009
PTA +280NM +.09%F +.09%P
PTA +1.1PL 2.84SCS -.3DPR 8%DCE
PTA +2.05T +1.46UDC +2.36FLC 94%R 8/2009
AGE X DAYS MILK DCRM % FAT % PRT DCRC
DHR 2-02 2 305 24800 4.0 991 3.4 834
365 29430 3.9 1161 3.4 996
GTPI *** 4-02 2 305 30800 100 4.5 1371 3.3 1018 100
O-BEE MANFRED JUSTICE-ET +2039G 365 35082 100 4.4 1539 3.3 1167 100
USA 122358313 100%RHA-NA TR TV TL TD --------------------------------------------------
7-07 94 EEEE GM 8/09 03/08/1998
PTA +1101M +77F +59P 99%R 8/2009
PTA +779NM +.14%F +.10%P 73%US GTPI
PTA +6.5PL 2.71SCS +2.7DPR 5%DCE DIXIE-LEE AARON-ET +1311G
PTA +.78T +.63UDC +1.58FLC 99%R 8/2009 USA 2265005 100%RHA-NA TV TL
CTPI CAN 04Y VG 88 GM 8/04 09/23/1994
WELCOME AARON PENEL +1637
USA 129820785 100%RHA-NA PTA +584M -9F +32P 99%R 8/2009
3-00 87 VVVVV DOM 04/16/2000 PTA +64NM -.12%F +.06%P 19%US
PTA -2.2PL 3.07SCS -2.5DPR 7%DCE
PTA +187M +26F +30P 82%R 8/2009 PTA +1.58T +1.87UDC +2.89FLC 99%R 8/2009
PTA +327NM +.08%F +.10%P CTPI
PTA +1.0PL 2.89SCS -1.2DPR 8%DCE WELCOME MERRILL PERKY-ET +1395
PTA +2.29T +2.77UDC +2.87FLC 80%R 8/2009 USA 15620914 100%RHA-NA
5-00 85 +E++V 10/31/1994
AGE X DAYS MILK DCRM % FAT % PRT DCRC
*** 2-00 3 305 27200 94 3.8 1025 3.3 888 94 PTA +421M +29F +24P 64%R 8/2009
365 32670 94 3.9 1260 3.3 1086 94 PTA +305NM +.05%F +.04%P
*** 4-08 3 305 30760 96 4.1 1274 3.3 1003 96 PTA +1.9PL 2.84SCS -.2DPR 9%DCE
365 35210 96 4.2 1480 3.3 1174 96 PTA +.19T +.60UDC +1.13FLC 60%R 8/2009
--------------------------------------------------
AGE X DAYS MILK DCRM % FAT % PRT DCRC
DHR 1-10 3 305 24290 3.2 789 3.0 730
365 29100 3.3 959 3.1 889
*** 3-02 3 305 30060 100 3.6 1077 3.0 900 99
337 32350 100 3.6 1172 3.0 984 99
*** 4-03 3 305 30710 100 3.5 1070 3.0 921 100
365 34690 100 3.6 1235 3.1 1073 100
*** 5-05 3 305 29090 99 3.3 951 3.0 873 99
365 31890 99 3.4 1074 3.0 963 99
LIFE 1589 136330 3.5 4785 3.1 4194
--------------------------------------------------
GTPI indicates genomic data was supplied to USDA.
Protein reported is true protein. 003444541 1516117 12/31/2009

100% Registered Holstein Ancestry (RHA-NA)
CTPI MGD OF 1HO07992 PALMER
WELCOME MERRILL PERKY-ET +1395 10/31/1994 FEMALE
USA 15620914 100%RHA-NA WILLIAM H. PECK
5-00 85 +E++V 285 WEST RIVER RD
SCHUYLERVILLE, NY 12871-1973
PTA +421M +29F +24P 64%R 8/2009 518/695-3375
PTA +305NM +.05%F +.04%P
PTA +1.9PL 2.84SCS -.2DPR 9%DCE
PTA +.19T +.60UDC +1.13FLC 60%R 8/2009
GTPI
AGE X DAYS MILK DCRM % FAT % PRT DCRC TRI-TOWN STEADY SPIPPER +969G
DHR 1-10 3 305 24290 3.2 789 3.0 730 USA 1829401 100%RHA-NA TV TL TD
365 29100 3.3 959 3.1 889 8-11 90 VEE GM 1/90 12/23/1979
*** 3-02 3 305 30060 100 3.6 1077 3.0 900 99
337 32350 100 3.6 1172 3.0 984 99 PTA -956M +14F -20P 99%R 8/2009
*** 4-03 3 305 30710 100 3.5 1070 3.0 921 100 PTA +46NM +.20%F +.03%P100%US
365 34690 100 3.6 1235 3.1 1073 100 PTA +1.3PL 2.73SCS -.6DPR12%DCE
*** 5-05 3 305 29090 99 3.3 951 3.0 873 99 PTA -.76T -.05UDC +.31FLC 99%R 8/2009
365 31890 99 3.4 1074 3.0 963 99 CTPI
LIFE 1589 136330 3.5 4785 3.1 4194 LONDONDALE MODEL FORD +991
--------------------------------------------------USA 11797524 100%RHA-NA
5-03 88 VEVE GMD DOM 01/22/1984
PTA +97M -11F +0P 86%R 8/2009
PTA +51NM -.06%F -.01%P
PTA +.9PL 2.90SCS +1.7DPR 8%DCE
PTA -1.08T -1.04UDC -.38FLC 85%R 8/2009
AGE X DAYS MILK DCRM % FAT % PRT DCRC
DHI 2-01 2 305 31270 3.7 1155 2.9 904
356 35423 3.7 1325 2.9 1035
GTPI DHI 3-02 2 305 30380 3.6 1098 3.2 967
LONDONDALE MERRILL-ET +1178G DHI 4-11 2 305 34260 4.1 1392 3.0 1015
USA 2076121 100%RHA-NA TV TL TD LIFE 966 100063 3.8 3815 3.0 3017
6-06 83 GVVV GM 2/99 04/03/1988 --------------------------------------------------
PTA +15M +24F -2P 99%R 8/2009
PTA +134NM +.09%F -.01%P 53%US GTPI
PTA +.5PL 3.05SCS +.3DPR10%DCE ART-ACRES NED BOY OSCAR-ET +1102G
PTA +.32T +.04UDC +1.81FLC 99%R 8/2009 USA 2035598 100%RHA-NA TL TD
CTPI 8-01 92 EEEE GM 8/98 08/29/1986
WELCOME OSCAR PROXY +1314
USA 14957621 100%RHA-NA PTA +418M +16F +18P 99%R 8/2009
2-09 78 GVG+G DOM 12/02/1992 PTA +119NM +.00%F +.02%P 44%US
PTA +.7PL 2.80SCS -.5DPR 9%DCE
PTA +587M +37F +43P 64%R 8/2009 PTA -.97T -1.45UDC +.36FLC 99%R 8/2009
PTA +329NM +.06%F +.10%P CTPI
PTA +1.7PL 2.78SCS -.7DPR 9%DCE WILLOW-MARSH-DRW PROZAC +1147
PTA -1.38T -.81UDC +.12FLC 61%R 8/2009 USA 14385218 100%RHA-NA
4-07 85 +E++V 02/17/1991
AGE X DAYS MILK DCRM % FAT % PRT DCRC
DHR 2-03 3 305 23240 4.0 930 3.2 753 PTA -194M +24F +15P 63%R 8/2009
365 27080 4.1 1102 3.3 901 PTA +177NM +.12%F +.08%P
DHR 3-06 3 305 28120 3.8 1063 3.4 953 PTA +1.3PL 2.86SCS -.7DPR 9%DCE
351 31770 3.8 1198 3.4 1074 PTA -.89T -.41UDC -.20FLC 62%R 8/2009
*** 4-08 3 305 30670 100 4.1 1272 3.4 1029 100
365 35990 100 4.1 1487 3.4 1220 100 AGE X DAYS MILK DCRM % FAT % PRT DCRC
LIFE 1370 113180 4.1 4621 3.5 3909 DHR 1-09 3 293 21560 4.1 876 3.1 675
--------------------------------------------------DHR 2-08 3 305 22320 4.3 963 3.3 747
365 26110 4.4 1159 3.4 887
DHR 4-00 3 305 26400 4.1 1080 3.0 805
365 30470 4.2 1279 3.1 954
DHR 5-05 3 173 16710 4.1 684 3.2 529
LIFE 1353 103540 4.3 4434 3.2 3365
--------------------------------------------------
GTPI indicates genomic data was supplied to USDA.
Protein reported is true protein. 003444541 1516153 12/31/2009

Source: http://cri-genetics.de/userfiles/file/PDF/Pedigrees/palmer_ped.pdf

Microsoft word - circular 03 con observaciones superadas dne

CIRCULAR 03 – 2008. La “CIRCULAR” es el mecanismo de comunicación oficial entre los titulares del Ministerio de Educación y los centros educativos del país, a fin de orientar el desarrollo de las actividades administrativas y pedagógicas, de conformidad al marco jurídico y a las normas vigentes. Según sea oportuno, el MINED emitirá una o varias circulares

Microsoft word - fluor bedraget.doc

Fluor bedraget Af Dorte Krog Jensen Farmakonom De fleste af os associerer fluor med sunde tænder og udsigten til nul huller. Ikke desto mindre er historien om, hvordan fluor havnede i din tandpasta et helt særligt, utroligt og grumt eventyr. Eventyret inkluderer nogen af de mest omtalte hændelser i verden – eksplosionen af atombomben i Hiroshima for eksempel. Og historiens krogede veje fører

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