Tadalafil entfaltet seine Wirkung über eine selektive Hemmung der PDE5, wodurch die Konzentration von cGMP im glatten Muskelgewebe stabil bleibt. Diese biochemische Modulation resultiert in einer langanhaltenden Relaxation der Gefäßwände. Der Wirkstoff wird nach oraler Einnahme effizient resorbiert, mit einer Bioverfügbarkeit von rund 80 %. Seine Halbwertszeit von bis zu 36 Stunden ist innerhalb dieser Substanzklasse außergewöhnlich. Abgebaut wird er in der Leber, hauptsächlich durch CYP3A4, mit anschließender biliärer Exkretion. Typische unerwünschte Wirkungen entstehen durch eine verstärkte Vasodilatation, etwa Kopfschmerzen oder Flush. Pharmakologisch wird cialis generika vor allem durch die verlängerte Wirkungsdauer charakterisiert.

Section6uk.pmd

The following table is only meant as guidance. Under normal domistic conditions an acceptable life span can beexpected, if those in the table indicated polymered medicaments are used.
Character explanation:
A: good, suitable for continuous usage.
B: satisfactory, suitable for periodic usage.
F: above average, suitable for periodic or seldom usage.
O: no information available at this moment.
X: not recommendable.
Chemical table - rubber, continued at next page Chemical table - rubber, continued at next page Chemical table - rubber, continued at next page Chemical table - rubber, continued at next page Chemical table - rubber, continued at next page Chemical table - rubber, continued at next page Chemical table - rubber, continued at next page Chemical table - rubber, continued at next page CHEMICAL TABLE - PTFE
Please notice: The data in this table are obtained at a 21° fluid temperature, higher temperatures can change the
adjustments. All data in this table are only meant as guidance and reservations should be taken accordingly. Tests
during actual conditions are strongly advisable.
Character explanation:
A: excellent, B: good, C: no information available, X: not suitable.
Hose end fittings material
Hose end fittings material
Chemical name
Chemical name
Chemical table - PTFE, continued at next page Hose End Fitting Material
Hose End Fitting Material
Chemical name
Chemical name
Kemikalietabel - PTFE, fortsættes på næste side Hose end fittings material
Chemical name
CHEMICAL TABLE - SYNTHETIC MATEIAL HOSES
Character explanation:
G: good, b: poor, L: limited, SP: Nobel Plastiques special product, *: better for PEBD, **: better for PEHD
Chemical table - Synthetic material hoses, continued at next page Ethylene glycol monoethyl etherEthyl mercaptan Chemical table - Synthetic material hoses, continued at next page Potassium hydroxidePotassium hydroxide 10 % Chemical table - Synthetic material hoses, continued at next page Character explanation:
G: good, b: poor

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