Tadalafil entfaltet seine Wirkung über eine selektive Hemmung der PDE5, wodurch die Konzentration von cGMP im glatten Muskelgewebe stabil bleibt. Diese biochemische Modulation resultiert in einer langanhaltenden Relaxation der Gefäßwände. Der Wirkstoff wird nach oraler Einnahme effizient resorbiert, mit einer Bioverfügbarkeit von rund 80 %. Seine Halbwertszeit von bis zu 36 Stunden ist innerhalb dieser Substanzklasse außergewöhnlich. Abgebaut wird er in der Leber, hauptsächlich durch CYP3A4, mit anschließender biliärer Exkretion. Typische unerwünschte Wirkungen entstehen durch eine verstärkte Vasodilatation, etwa Kopfschmerzen oder Flush. Pharmakologisch wird cialis generika vor allem durch die verlängerte Wirkungsdauer charakterisiert.

Microsoft word - knh 413 dm case study.docx

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29@/&@A2"E0&9"/&2(&E00?&90#&D$((4&B$38(/0&$0F0$/&(F0#A@B92&"/&/90&/$00?/=&&& 5<= k3/2&D0C(#0&13/"A&@/&4@/89"#B04;&90#&L(290#&"/E/&%(3;&^7%&C#@0A4&Q9(&(QA/&"& 90"$29&C((4&/2(#0&2($4&L0&29"2&13/"A&/9(3$4&3/0&120F@"&@A/20"4&(C&"#2@C@8@"$&/Q0020A0#/&(#&/3B"#=&&U9"2&4(&%(3&29@AEV_&&U9"2&Q@$$&%(3&20$$&13/"A&"A4&90#&L(290#V& • 120F@"&@/&B"@A@AB&?(?3$"#@2%&"L(AB&290&4@"D02@8&8(LL3A@2%&D08"3/0&@2& /2@L3$"20/&290&#0$0"/0&(C&@A/3$@A&"A4&A(#L"$@]0/&290&#0/?(A/0&2(& B$38(/0=&&G&Q(3$4&"4F@/0&90#&2(&2"E0&8"32@(A&Q90A&8(A/3L@AB&120F@"&D08"3/0&@2&8"A&$(Q0#&D$((4&/3B"#&"A4&8"A&@A20#C0#0&Q@29&@A/3$@A&"A4&(290#&L04@8"2@(A/=&&G&Q(3$4&#08(LL0A4&29"2&13/"A&/2"%&"Q"%&C#(L& 120F@"&@A&(#40#&2(&0A/3#0&290#0&@/&A(&@A20#C0#0A80&Q@29&@A/3$@A&$0F0$/&"A4&L04@8"2@(A=&&& Intensive insulin therapy: Achieving tight blood sugar control - MayoClinic.com. Mayo Clinic. Retrieved March 25, 2012, from http://www.mayoclinic.com/health/intensive-insulin-therapy/DA00088 Nelms, M., Sucher, K. P., Lacey, K., & Roth, S. L. (2011). Nutrition Therapy and Pathophysiology. Belmont, California: Wadsworth, Cengage Learning. What Is an IV Piggyback? wiseGEEK: clear answers for common questions. Retrieved March 25, 2012, from http://www.wisegeek.com/what-is-an-iv-piggyback.htm

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