Chin J Nucl M ed, Apr 2002, Vol 22, No. 2 18F 标记的正电子放射性药物及其临床应用 fluorocholine( FCH ) 2- 18 F-fluoroethylcholine fluoro- 6-thia- heptadecanioc acid( FTHA) , 15- 18F- fluoro- 3-oxa- pentadecnoate( FOP) Chin J Nucl M ed, Apr 2002, Vol 22, No. 2 ( 3-fluoropropyl) thio-l 1, 2, 5, thiadiazo- 2, 5, 6-tetrahydro-1Hmethylpyridine ( 18 F- FP- 18F- norchlorofluoroepibatidine ( NFEP) 18F- azetidinylmethoxy) pyridine( 6-18F- A85380 18F- 2, 3- dimethoxy- N-[ 9- ( 4- fluorobenzyl)- 9- azabicyclo ( 3, 3, 1 ) nonan-3-beta- yl] benza- ( fluorobenzyl ) piperidin- 4- yl ] benzamide ( 1-methy-l 4- piperidinyl)- 1H- indole ( 18F- Lu9- Chin J Nucl M ed, Apr 2002, Vol 22, No. 2 F-fluorohexyl )-N- methylpropargylamin ( 18 F- zylpiperidin- 4- yl )- 2- 18 F- fluorobenzamide ( 4- fluorophenyl )- propyl ) piperazine ] ( 18 F- propoxy) methyl] guanine( FHPG) 18F- 9- [ ( 3- fluoro-1- hydroxy-2- propoxy ) butyl ] guanine fluoroethyl)-6- o- desmethyldiprenorphine( 18F- Chin J Nucl M ed, Apr 2002, Vol 22, No. 2 6 Goodman MM, Kilts CD , Keil R, et al. 18F- labelled FECNT: a selective radioligand for PET imaging of brain dopamine transporters.
7 Houle S , Dasilva JN , Vilson AA , et al. Imag- 8 Sobrio F, Amohtari M, Gourand F, et al. Ra- diosynt hesis of 18F- Lu29- 024: a potential PET 1 Grierson JR , Shields AF. Radiosynthesis of 3c- ligand for brain imaging of the serotonergic 5- HT2 receptor. Biol Org Med Chem, 2000, 8: imaging of cellar prol if eration in vivo. Nucl 9 Villemagene VL, Hort i A, Scheffel U , et al.
2 Taylor M, Wallhaus TR, Degrado TR, et al.
Imaging nicotinic acetylcholine receptors with 18F- An evaluat ion of myocardial fat ty acid and glu- cose uptake using PET with 18F- f luoro- 6- thia- hepadecanoic acid and 18F-FDG in pat ient with 10 Elsinga PH, Vos MG , Waarde AV, et al. ( S , 18F-A-melanocyte stimulatinghormone(MSH) , congestion heart failure. J Nucl M ed, 2001, S )- and ( S , R )- 1c- 18F- fluorocarazolol, ligands for the visual izat ion of pulmonary beta- adrener- gic receptors with PET. Nucl Med Biol, 1996, 3 Christian BT, Narayanan TK, Shi B, et al.
Quantitation of st riatal and ext rastriat al D dopamine receptors using PET imaging of 18F- 11 Varagnolo L, Stokkel MP, Mazzi U, et al. 18F fallypride in nonhuman primat es. Synapse, labeled radiopharmaceut icals for PET in oncolo- gy, excluding FDG. Nucl M ed Biol, 2000, 27: 4 G age HD , Voytko ML, Richard LE, et al. Rre- ducibility of repeated measures of cholinergi c 12 Shiue C, Shiue GG , Benard F, et al. N- ( n- t erminal density using 18F- ( + )- 4- fluorobenzy-l benzylpiperidin- 4- yl )- 2- 18 F- fluorobenzmide: a potent ial ligand of breast cancer. Nucl Med B-i trozamicol and PET in the rhesus monkey brain.
13 Meera I, Jorge R, Barrio MN , et al. 8- 18F- flu- 5 N ader MA , Grant KA, Gage HD, et al. PET imaging of dopamine D receptors with 18F- flu- oropenciclovir: an improved report er probe for 8- [ (4c- 18F-fluorobenzyl) amino] suberate( SFBS) clebopride in monkeys: effects of isoflurane- and ketamine- induced anesthesia. N europsy- vo using PET. J Nucl Med, 2001, 42: 96- 105.
chopharmacology, 1999, 12: 589- 596.

Source: http://www.jysy.cc/uploadfile/ckeditor/files/2012-04-28/18_F%E6%A0%87%E8%AE%B0%E7%9A%84%E6%AD%A3%E7%94%B5%E5%AD%90%E6%94%BE%E5%B0%84%E6%80%A7%E8%8D%AF%E7%89%A9%E5%8F%8A%E5%85%B6%E4%B8%B4%E5%BA%8A%E5%BA%94%E7%94%A8.pdf

Protecting public health by

FDA Conducts Preliminary Review of Agency’s Diversion and Counterfeit Criminal Case Information September 2011 “Drug counterfeiting, diversion, cargo theft and economically motivated adulteration are crimes of opportunity, and the opportunity is flourishing because of the dramatic way our world has changed in a relatively short period of time.” Executive Summary T

Science art and drug discovery, a personal perspective

Science, Art and Drug Discovery, A Personal Perspective Simon F. Campbell, PhD FRS Formerly Senior Vice President, WW Discovery, Pfizer Central Research The pharmaceutical industry is under intense pressure to increase productivity, and drug discovery is undergoing a paradigm shift whereby the explosion in genome sciences and new technologies is being harnessed to produce innovative th

Copyright © 2010-2014 Metabolize Drugs Pdf