Tadalafil entfaltet seine Wirkung über eine selektive Hemmung der PDE5, wodurch die Konzentration von cGMP im glatten Muskelgewebe stabil bleibt. Diese biochemische Modulation resultiert in einer langanhaltenden Relaxation der Gefäßwände. Der Wirkstoff wird nach oraler Einnahme effizient resorbiert, mit einer Bioverfügbarkeit von rund 80 %. Seine Halbwertszeit von bis zu 36 Stunden ist innerhalb dieser Substanzklasse außergewöhnlich. Abgebaut wird er in der Leber, hauptsächlich durch CYP3A4, mit anschließender biliärer Exkretion. Typische unerwünschte Wirkungen entstehen durch eine verstärkte Vasodilatation, etwa Kopfschmerzen oder Flush. Pharmakologisch wird cialis generika vor allem durch die verlängerte Wirkungsdauer charakterisiert.

Microsoft word - mdg5214_keyword search statement atm

(warfarin OR coumadin OR coumadine) AND
(resistance OR drug resistance OR resist*) AND
(review OR reviews)
(("warfarin"[MeSH Terms] OR "warfarin"[All Fields]) OR ("warfarin"[MeSH Terms] OR
"warfarin"[All Fields] OR "coumadin"[All Fields]) OR ("warfarin"[MeSH Terms] OR
"warfarin"[All Fields] OR "coumadine"[All Fields])) AND (resistance[All Fields] OR ("drug
resistance"[MeSH Terms] OR ("drug"[All Fields] AND "resistance"[All Fields]) OR "drug
resistance"[All Fields]) OR (resist[All Fields] OR resist/air[All Fields] OR resist/avoid[All
Fields] OR resist/deter[All Fields] OR resist/metabolize[All Fields] OR resist/peradeniya[All
Fields] OR resist/respond[All Fields] OR resist/tolerate[All Fields] OR resist/yield[All Fields]
OR resist'[All Fields] OR resist's[All Fields] OR resistaant[All Fields] OR resistability[All
Fields] OR resistable[All Fields] OR resistace[All Fields] OR resistae[All Fields] OR
resistaid[All Fields] OR resistaidtrade[All Fields] OR resistaiple[All Fields] OR resistal[All
Fields] OR resistan[All Fields] OR resistanc[All Fields] OR resistanca[All Fields] OR
resistancce[All Fields] OR resistance[All Fields] OR resistance/1[All Fields] OR
resistance/100[All Fields] OR resistance/acceptance[All Fields] OR resistance/activity[All
Fields] OR resistance/adaptation[All Fields] OR resistance/adaptive[All Fields] OR
resistance/adefovir[All Fields] OR resistance/adv[All Fields] OR resistance/aerobic[All
Fields] OR resistance/agility[All Fields] OR resistance/arm[All Fields] OR
resistance/arterial[All Fields] OR resistance/assistance[All Fields] OR
resistance/atherogenic[All Fields] OR resistance/attempts[All Fields] OR resistance/avr[All
Fields] OR resistance/balance[All Fields] OR resistance/blood[All Fields] OR
resistance/breast[All Fields] OR resistance/capacitance[All Fields] OR
resistance/cardiovascular[All Fields] OR resistance/cell[All Fields] OR
resistance/cell/generation[All Fields] OR resistance/change[All Fields] OR
resistance/chemosensitivity[All Fields] OR resistance/chronological[All Fields] OR
resistance/clinical[All Fields] OR resistance/collateral[All Fields] OR
resistance/compatibility[All Fields] OR resistance/compensatory[All Fields] OR
resistance/competence[All Fields] OR resistance/compliance[All Fields] OR
resistance/concentration[All Fields] OR resistance/conductance[All Fields] OR
resistance/control[All Fields] OR resistance/coordination[All Fields] OR
resistance/current[All Fields] OR resistance/daunorubicin[All Fields] OR
resistance/decreased[All Fields] OR resistance/defence[All Fields] OR
resistance/deficiency[All Fields] OR resistance/dependence[All Fields] OR
resistance/detected[All Fields] OR resistance/detoxification[All Fields] OR
resistance/diabetes[All Fields] OR resistance/diabetic[All Fields] OR
resistance/dicarboxylate[All Fields] OR resistance/diffusion[All Fields] OR
resistance/disinterest[All Fields] OR resistance/dynamic[All Fields] OR
resistance/dyslipidemia[All Fields] OR resistance/elastance[All Fields] OR
resistance/endothelial[All Fields] OR resistance/endurance[All Fields] OR
resistance/engagement[All Fields] OR resistance/escape[All Fields] OR resistance/factor[All
Fields] OR resistance/fat[All Fields] OR resistance/fear[All Fields] OR
resistance/flexibility[All Fields] OR resistance/fluid[All Fields] OR resistance/found[All
Fields] OR resistance/frequency[All Fields] OR resistance/fv[All Fields] OR resistance/g[All
Fields] OR resistance/germplasm[All Fields] OR resistance/gestational[All Fields] OR
resistance/glucose[All Fields] OR resistance/gm[All Fields] OR resistance/height[All Fields]
OR resistance/height2[All Fields] OR resistance/high[All Fields] OR resistance/homeostasis[All Fields] OR resistance/hyperglycemia[All Fields] OR resistance/hyperinsulinaemia[All Fields] OR resistance/hyperinsulinemia[All Fields] OR resistance/hyperinsulinemia/hyperglycemia[All Fields] OR resistance/hyperinsulinemic[All Fields] OR resistance/hyperinsulinism[All Fields] OR resistance/hyperlipidaemia[All Fields] OR resistance/hypersensitivity[All Fields] OR resistance/hypersusceptibility[All Fields] OR resistance/hypertension[All Fields] OR resistance/hypertriglyceridemia[All Fields] OR resistance/immunity[All Fields] OR resistance/impact[All Fields] OR resistance/impaired[All Fields] OR resistance/impedance[All Fields] OR resistance/inflammation[All Fields] OR resistance/inhibition[All Fields] OR resistance/innate[All Fields] OR resistance/insensitivity[All Fields] OR resistance/inspiratory[All Fields] OR resistance/insulinemia[All Fields] OR resistance/intermediate[All Fields] OR resistance/international[All Fields] OR resistance/intolerance[All Fields] OR resistance/intrathoracic[All Fields] OR resistance/isometric[All Fields] OR resistance/lipodystrophy[All Fields] OR resistance/log[All Fields] OR resistance/long[All Fields] OR resistance/loss[All Fields] OR resistance/low[All Fields] OR resistance/lvep[All Fields] OR resistance/macrolide[All Fields] OR resistance/measurement[All Fields] OR resistance/meca[All Fields] OR resistance/membrane[All Fields] OR resistance/metabolic[All Fields] OR resistance/moisturization[All Fields] OR resistance/motivation[All Fields] OR resistance/multidrug[All Fields] OR resistance/muscle[All Fields] OR resistance/mutagenesis[All Fields] OR resistance/mutator[All Fields] OR resistance/new[All Fields] OR resistance/no[All Fields] OR resistance/nodulation[All Fields] OR resistance/nodulation/cell[All Fields] OR resistance/nodulation/division[All Fields] OR resistance/nonalcoholic[All Fields] OR resistance/nonconsent[All Fields] OR resistance/obesity[All Fields] OR resistance/pancreatic[All Fields] OR resistance/parenchymal[All Fields] OR resistance/peripheral[All Fields] OR resistance/physiology[All Fields] OR resistance/power[All Fields] OR resistance/pyrabactin[All Fields] OR resistance/reactance[All Fields] OR resistance/reactance/impedance[All Fields] OR resistance/reactivation[All Fields] OR resistance/recovery[All Fields] OR resistance/recurrence[All Fields] OR resistance/reduced[All Fields] OR resistance/refraction[All Fields] OR resistance/refractoriness[All Fields] OR resistance/refusal[All Fields] OR resistance/regulatory[All Fields] OR resistance/reinfection[All Fields] OR resistance/relapse[All Fields] OR resistance/relapse/progression[All Fields] OR resistance/relapse/transformation[All Fields] OR resistance/relapses[All Fields] OR resistance/release[All Fields] OR resistance/renin/adiposity[All Fields] OR resistance/reporter[All Fields] OR resistance/resilience[All Fields] OR resistance/resistance[All Fields] OR resistance/response[All Fields] OR resistance/retention[All Fields] OR resistance/reversion[All Fields] OR resistance/right[All Fields] OR resistance/secretion[All Fields] OR resistance/selection[All Fields] OR resistance/sensibility[All Fields] OR resistance/sensitivity[All Fields] OR resistance/sequestration[All Fields] OR resistance/serum[All Fields] OR resistance/severity[All Fields] OR resistance/shear[All Fields] OR resistance/short[All Fields] OR resistance/slow[All Fields] OR resistance/solution[All Fields] OR resistance/spectrum[All Fields] OR resistance/stanford[All Fields] OR resistance/static[All Fields] OR resistance/strain[All Fields] OR resistance/strength[All Fields] OR resistance/stress[All Fields] OR resistance/suction[All Fields] OR resistance/survival[All Fields] OR resistance/susceptibilities[All Fields] OR resistance/susceptibility[All Fields] OR resistance/susceptibilty[All Fields] OR resistance/susceptible[All Fields] OR resistance/susceptiblity[All Fields] OR resistance/systemic[All Fields] OR resistance/target[All Fields] OR resistance/temperature[All Fields] OR resistance/thermal[All Fields] OR resistance/time[All Fields] OR resistance/tissue[All Fields] OR resistance/tolerance[All Fields] OR resistance/toms[All Fields] OR resistance/tone[All Fields] OR resistance/total[All Fields] OR resistance/toxicity[All Fields] OR resistance/treatment[All Fields] OR resistance/type[All Fields] OR resistance/umbilical[All Fields] OR resistance/verapamil[All Fields] OR resistance/viral[All Fields] OR resistance/virologic[All Fields] OR resistance/virulence[All Fields] OR resistance/virulent[All Fields] OR resistance/viscosity[All Fields] OR resistance/volthour[All Fields] OR resistance/vulnerability[All Fields] OR resistance/weight[All Fields] OR resistance/worm[All Fields] OR resistance/worsening[All Fields] OR resistance'[All Fields] OR resistance''[All Fields] OR resistance's[All Fields] OR resistance1[All Fields] OR resistance11[All Fields] OR resistance2[All Fields] OR resistance3[All Fields] OR resistance4[All Fields] OR resistance4/glucan[All Fields] OR resistance8[All Fields] OR resistance8/abcg36[All Fields] OR resistance9[All Fields] OR resistanceagainst[All Fields] OR resistanceamong[All Fields] OR resistanceand[All Fields] OR resistancecaliber[All Fields] OR resistanced[All Fields] OR resistancedetermining[All Fields] OR resistanceetween[All Fields] OR resistanceevolution[All Fields] OR resistancein[All Fields] OR resistanceindex[All Fields] OR resistancekurven[All Fields] OR resistancel[All Fields] OR resistancemediated[All Fields] OR resistancemeter[All Fields] OR resistancemutations[All Fields] OR resistanceof[All Fields] OR resistancerelated[All Fields] OR resistances[All Fields] OR resistances/tolerances[All Fields] OR resistances'[All Fields] OR resistancestress[All Fields] OR resistancesusceptibility[All Fields] OR resistanceto[All Fields] OR resistancetrained[All Fields] OR resistancevars[All Fields] OR resistancewas[All Fields] OR resistancewith[All Fields] OR resistancia[All Fields] OR resistancies[All Fields] OR resistanct[All Fields] OR resistancto[All Fields] OR resistancy[All Fields] OR resistand[All Fields] OR resistane[All Fields] OR resistanec[All Fields] OR resistaneza[All Fields] OR resistanfce[All Fields] OR resistans[All Fields] OR resistanse[All Fields] OR resistant[All Fields] OR resistant/'remus[All Fields] OR resistant/1[All Fields] OR resistant/1/iwate[All Fields] OR resistant/11[All Fields] OR resistant/98[All Fields] OR resistant/acetate[All Fields] OR resistant/acidic[All Fields] OR resistant/adhesive[All Fields] OR resistant/alondra[All Fields] OR resistant/alpha[All Fields] OR resistant/ambivalent[All Fields] OR resistant/ca[All Fields] OR resistant/chronic[All Fields] OR resistant/constitutively[All Fields] OR resistant/controls[All Fields] OR resistant/ctl[All Fields] OR resistant/d[All Fields] OR resistant/dependent[All Fields] OR resistant/deterrent[All Fields] OR resistant/diabetic[All Fields] OR resistant/dormant[All Fields] OR resistant/drug[All Fields] OR resistant/dyslipidemic[All Fields] OR resistant/er[All Fields] OR resistant/estrogen[All Fields] OR resistant/extensively[All Fields] OR resistant/extremely[All Fields] OR resistant/foscarnet[All Fields] OR resistant/glucose[All Fields] OR resistant/gus[All Fields] OR resistant/high[All Fields] OR resistant/hyperinsulinemic[All Fields] OR resistant/hyperlipidemic[All Fields] OR resistant/hypersensitive[All Fields] OR resistant/hypertriglyceridemic/obese[All Fields] OR resistant/hyporesponsive[All Fields] OR resistant/i50[All Fields] OR resistant/impaired[All Fields] OR resistant/independent[All Fields] OR resistant/inflamed[All Fields] OR resistant/intermediate[All Fields] OR resistant/intermediately[All Fields] OR resistant/intolerant[All Fields] OR resistant/invasive[All Fields] OR resistant/klebsiella[All Fields] OR resistant/medically[All Fields] OR resistant/metabolic[All Fields] OR resistant/metastatic[All Fields] OR resistant/methicillin[All Fields] OR resistant/methylene[All Fields] OR resistant/ml[All Fields] OR resistant/moxidectin[All Fields] OR resistant/obese[All Fields] OR resistant/pathogen[All Fields] OR resistant/penicillin[All Fields] OR resistant/persistent[All Fields] OR resistant/platinum[All Fields] OR resistant/pretreated[All Fields] OR resistant/prion[All Fields] OR resistant/progressive[All Fields] OR resistant/proteus[All Fields] OR resistant/proteuslike[All Fields] OR resistant/r[All Fields] OR resistant/rapp[All Fields] OR resistant/recital[All Fields] OR resistant/recovered[All Fields] OR resistant/recurrent[All Fields] OR resistant/refractory[All Fields] OR resistant/relapsed[All Fields] OR resistant/relapsing[All Fields] OR resistant/remus[All Fields] OR resistant/resilient[All Fields] OR resistant/resistant[All Fields] OR resistant/second[All Fields] OR resistant/sensitive[All Fields] OR resistant/seven[All Fields] OR resistant/stress[All Fields] OR resistant/susceptible[All Fields] OR resistant/t[All Fields] OR resistant/teicoplanin[All Fields] OR resistant/thymidine[All Fields] OR resistant/tolerant[All Fields] OR resistant/toxic[All Fields] OR resistant/treatment[All Fields] OR resistant/type[All Fields] OR resistant/unresponsive[All Fields] OR resistant/unwilling[All Fields] OR resistant/very[All Fields] OR resistant/virulent[All Fields] OR resistant/weakly[All Fields] OR resistant'[All Fields] OR resistant's[All Fields] OR resistant1[All Fields] OR resistant11[All Fields] OR resistant12[All Fields] OR resistant2[All Fields] OR resistant3[All Fields] OR resistant4[All Fields] OR resistant5[All Fields] OR resistant6[All Fields] OR resistanta[All Fields] OR resistantacid[All Fields] OR resistantance[All Fields] OR resistantce[All Fields] OR resistantcell[All Fields] OR resistante[All Fields] OR resistantes[All Fields] OR resistanth[All Fields] OR resistantiae[All Fields] OR resistantlike[All Fields] OR resistantlpr[All Fields] OR resistantly[All Fields] OR resistantmalaria[All Fields] OR resistantplants[All Fields] OR resistantplus[All Fields] OR resistantpneumococci[All Fields] OR resistantpseudomonas[All Fields] OR resistantr[All Fields] OR resistants[All Fields] OR resistantstrain[All Fields] OR resistantstrains[All Fields] OR resistantstreptococcus[All Fields] OR resistanttb[All Fields] OR resistantto[All Fields] OR resistantwomen[All Fields] OR resistanz[All Fields] OR resistanza[All Fields] OR resistanzspektrum[All Fields] OR resistaphylin[All Fields] OR resistart[All Fields] OR resistasnce[All Fields] OR resistat[All Fields] OR resistates[All Fields] OR resistatt[All Fields] OR resistauce[All Fields] OR resistault[All Fields] OR resiste[All Fields] OR resisted[All Fields] OR resisten[All Fields] OR resistenant[All Fields] OR resistence[All Fields] OR resistence1[All Fields] OR resistences[All Fields] OR resistenci[All Fields] OR resistencia[All Fields] OR resistenciade[All Fields] OR resistenciae[All Fields] OR resistenciajanak[All Fields] OR resistenciajara[All Fields] OR resistencial[All Fields] OR resistencias[All Fields] OR resistencija[All Fields] OR resistencije[All Fields] OR resistency[All Fields] OR resistenes[All Fields] OR resistenica[All Fields] OR resistens[All Fields] OR resistensbestamning[All Fields] OR resistensbestemmelse[All Fields] OR resistensbestemmelser[All Fields] OR resistensbildningens[All Fields] OR resistensdebatt[All Fields] OR resistense[All Fields] OR resistensen[All Fields] OR resistensfaktorer[All Fields] OR resistensforhallanden[All Fields] OR resistensforhallandena[All Fields] OR resistensforhold[All Fields] OR resistensforholdene[All Fields] OR resistenshoten[All Fields] OR resistensmekanismer[All Fields] OR resistensmonster[All Fields] OR resistensmonsteret[All Fields] OR resistensmonstrets[All Fields] OR resistensnedsettelse[All Fields] OR resistensokning[All Fields] OR resistensproblem[All Fields] OR resistensproblematiken[All Fields] OR resistensproblemer[All Fields] OR resistensproblemets[All Fields] OR resistensprove[All Fields] OR resistensprovning[All Fields] OR resistenssi[All Fields] OR resistenssit[All Fields] OR resistensspektra[All Fields] OR resistenstabletter[All Fields] OR resistenstestning[All Fields] OR resistensudvikling[All Fields] OR resistensudviklingen[All Fields] OR resistensundersogelser[All Fields] OR resistensundersokning[All Fields] OR resistensundersokningar[All Fields] OR resistensutveckling[All Fields] OR resistensutvecklingen[All Fields] OR resistensutvikling[All Fields] OR resistent[All Fields] OR resistent1[All Fields] OR resistenta[All Fields] OR resistentae[All Fields] OR resistente[All Fields] OR resistentem[All Fields] OR resistenten[All Fields] OR resistenter[All Fields] OR resistentes[All Fields] OR resistenti[All Fields] OR resistenti'aj'anak[All Fields] OR resistentia[All Fields] OR resistentiaban[All Fields] OR resistentiae[All Fields] OR resistentiae'[All Fields] OR resistentiahoz[All Fields] OR resistentiaja[All Fields] OR resistentiajainak[All Fields] OR resistentiajanak[All Fields] OR resistentiajara[All Fields] OR resistentiajarol[All Fields] OR resistentiara[All Fields] OR resistentiarol[All Fields] OR resistentiat[All Fields] OR resistentie[All Fields] OR resistentiebepaling[All Fields] OR resistentiebepalingen[All Fields] OR resistentiemechanismen[All Fields] OR resistentiepatronen[All Fields] OR resistentiepeiling[All Fields] OR resistentieproblemen[All Fields] OR resistentievraagstuk[All Fields] OR resistention[All Fields] OR resistentit[All Fields] OR resistentni[All Fields] OR resistentnich[All Fields] OR resistentniho[All Fields] OR resistentnost[All Fields] OR resistentnost'[All Fields] OR resistentnosti[All Fields] OR resistentnye[All Fields] OR resistentnykh[All Fields] OR resistentnymi[All Fields] OR resistents[All Fields] OR resistentti[All Fields] OR resistenttien[All Fields] OR resistentzuchtung[All Fields] OR resistenz[All Fields] OR resistenza[All Fields] OR resistenzanalyse[All Fields] OR resistenzanderung[All Fields] OR resistenzanderungen[All Fields] OR resistenzausbildung[All Fields] OR resistenzbarriere[All Fields] OR resistenzbeeinflussender[All Fields] OR resistenzbegriff[All Fields] OR resistenzbestimmung[All Fields] OR resistenzbestimmungen[All Fields] OR resistenzbestimmungsmethoden[All Fields] OR resistenzbeurteilung[All Fields] OR resistenzbildes[All Fields] OR resistenzbildung[All Fields] OR resistenzdarstellung[All Fields] OR resistenzdeterminanten[All Fields] OR resistenzdurchbrechung[All Fields] OR resistenze[All Fields] OR resistenzeandel[All Fields] OR resistenzeffektes[All Fields] OR resistenzeigenschaften[All Fields] OR resistenzen[All Fields] OR resistenzentstehung[All Fields] OR resistenzentwicklung[All Fields] OR resistenzentwicklungen[All Fields] OR resistenzerhalten[All Fields] OR resistenzerhohung[All Fields] OR resistenzerscheinungen[All Fields] OR resistenzfaktor[All Fields] OR resistenzfaktoren[All Fields] OR resistenzfaktors[All Fields] OR resistenzfalle[All Fields] OR resistenzfordernden[All Fields] OR resistenzfrage[All Fields] OR resistenzgene[All Fields] OR resistenzgerechter[All Fields] OR resistenzgeschwachten[All Fields] OR resistenzhaufigkeit[All Fields] OR resistenzhemmung[All Fields] OR resistenzia[All Fields] OR resistenziale[All Fields] OR resistenzinduktion[All Fields] OR resistenzkoppelung[All Fields] OR resistenzkorrelation[All Fields] OR resistenzkrankheit[All Fields] OR resistenzkurve[All Fields] OR resistenzlage[All Fields] OR resistenzmangel[All Fields] OR resistenzmarker[All Fields] OR resistenzmechanismen[All Fields] OR resistenzmechanismus[All Fields] OR resistenzminderung[All Fields] OR resistenzmonitoring[All Fields] OR resistenzmuster[All Fields] OR resistenzmusterspektrum[All Fields] OR resistenzmutationen[All Fields] OR resistenzneigung[All Fields] OR resistenzphanomene[All Fields] OR resistenzphase[All Fields] OR resistenzplasmide[All Fields] OR resistenzplasmiden[All Fields] OR resistenzproben[All Fields] OR resistenzproblem[All Fields] OR resistenzprobleme[All Fields] OR resistenzproblems[All Fields] OR resistenzprofil[All Fields] OR resistenzprufung[All Fields] OR resistenzprufungen[All Fields] OR resistenzquote[All Fields] OR resistenzquoten[All Fields] OR resistenzrate[All Fields] OR resistenzraten[All Fields] OR resistenzschwache[All Fields] OR resistenzschwaechung[All Fields] OR resistenzsituation[All Fields] OR resistenzspektren[All Fields] OR resistenzspektrum[All Fields])) AND (("review"[Publication Type] OR "review literature as topic"[MeSH Terms] OR "review"[All Fields]) OR ("review"[Publication Type] OR "review literature as topic"[MeSH Terms] OR "reviews"[All Fields]))

Source: http://www.lib.nus.edu.sg/ilp/mdrt/MDG5214_Keyword%20search%20statement%20ATM.pdf