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Department of General Surgical Science (Surgery I), Department of General Surgical Science The Department of General Surgical Science of the Gunma University Graduate School of Medicine was established in 1943. This year marks its 62nd anniversary. Six years have passed since I was appointed as replacement to Dr. Yukio Nagamachi at Gunma University in 1995. Throughout the years, I have been thinking how to carry on with the great works and legacy that predecessors like Prof. Nagamachi has established in this Department. To be the best in both worlds of medical practice and clinical research, it is needed to have an eccentric amount of inner strength to commit with our sweat and blood. Thus to maintain and build on to this legacy, I have decided to compile the works of the Department into an Annual Report. The increasingly diversifying and fractionalizing world of clinical research has prompted an enormous increase in the amount of cost and time it takes to complete a single study. In 2004, we published over 60 issues of English-written articles, but I deemed them far from satisfactory, both quantitatively and qualitatively. I want to make it my personal task to continue with the effort to improve in this area. For this, I would like to implore your continued support in this venture. The Department of General Surgical Science To all members of the Department of General Surgical Science, Congratulations upon your successful publication of this year’s Annual Report. The idea of compiling the English-written articles and issuing them as an Annual Report came to myself when I was appointed as a Professor in the Kyushu University Department of Surgery and Science in 1985. The publication of the Report began in 1986. I’m very happy and proud to know that one of my pupil, Dr. Kuwano, has successfully released this Annual Report as a member of the faculty of Gunma University. I would also like to compliment all of the members of the Department involved in this arduous task of compiling these English articles, one by one. Studies like these can only gain public appraisal when they are released in the form of compiled articles such as your Annual Report. Otherwise, even the greatest study will lose its true value. Furthermore, the Report would have to be compiled in English if it is to gain world-wide public attention. Dr. Kuwano has inherited these ideas. All this is owed to his predecessor, to Dr. Yukio Nagamachi’s great legacy and experience at the Department. Unfortunately, Dr. Nagamachi has passed away just recently before he had the chance to take a look at the actual publication. However, I firmly believe that his teachings will live on with the new legacy inherited by Dr. Kuwano, and that the publication of this Report will further contribute to the Department’s achievement in enhancement of medical science in our country. Lastly, I look forward to witness the advancement of this country’s medical science, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers Kuwano H, et al. Double endoscopic intraluminal operation for upper digestive tract diseases: proposal of a novel procedure. Ann. Surg. 239(1): 22-27, 2004. Kuwano H. et al. Malignant transformation of the mouse anorectal epithelium induced by an inoculated human cancer cell line. Dig. Dis. Sci. 49(11-12): 1912-1921, 2004. Kuwano H. et al. Cell density modulates the metastatic aggressiveness of a mouse colon cancer 17 cell line, colon 26. Oncology 67(5-6):441-449, 2004. Kuwano H. et al. Transthoracal partial resection or local excision of small esophageal carcinoma 26 with a radical mediastinal lymphadenectomy--proposal of limited operation for postoperative quality of life. Hepato-Gastroenterol. 51(60): 1631-1635, 2004. Kuwano H. et al. Considerable multiple esophageal carcinoma. Implications of a new clinical 31 entity. Hepato-Gastroenterol. 51(60): 1713-1716, 2004. Kuwano H. et al. Appraisal of the simultaneous right-thoracic and abdominal approach with 35 intrathoracic reconstruction after esophageal resection for patients with intrathoracic esophageal cancer. Hepato-Gastroenterol. 51(60): 1722-1728, 2004. Kuwano H. et al. Long myotomy of the esophagus and gastric cardia with a complete fundic 42 patch procedure for diffuse esophageal spasm. Hepato-Gastroenterol. 51(60): 1729-1731, 2004. Kato H. et al. Value of positron emission tomography in the diagnosis of recurrent oesophageal 45 carcinoma. Br. J. Surg. 91(8): 1004-1009, 2004. Kato H. et al. The effectiveness of planned esophagectomy after neoadjuvant chemoradiotherapy 51 for advanced esophageal carcinomas. Anticancer Res. 24(6): 4091-4096, 2004. 10. Tsukada K. et al. CT is useful for identifying patients with complicated appendicitis. Dig. Liver 57 11. Tsukada K. et al. Body fat accumulation and postoperative complications after abdominal 61 surgery. Am. Surg. 70(4): 347-351, 2004. 12. Tsukada K. et al. Interferon-gamma and granulocyte colony-stimulating factor in bronchoalveolar 66 lavage fluid after oesophagectomy. Dig. Liver Dis. 36(9): 572-576, 2004. 13. Osawa H. et al. Prognostic value of the expression of smad6 and smad7, as inhibitory smads of 71 the TGF-ßsuperfamily, in esophageal squamous cell carcinoma Anticancer Res. 24(6): 14. Fukuchi M. et al. Increased expressio n of c-Ski as a co-repressor in transforming growth 78 factor-beta signaling correlates with progression of esophageal squamous cell carcinoma. Int. J. 15. Fukuchi M. et al. Inverse correlation between expression levels of p27 and the ubiquitin ligase 84 subunit Skp2 in early esophageal squamous cell carcinoma. Anticancer Res. 24(2B): 777-783, 16. Fukuchi M. et al. Plasma level of transforming growth factor beta1 measured from the azygos 92 vein predicts prognosis in patie nts with esophageal cancer. Clin. Cancer Res. 10(8): 2738-2741, 17. Miyazaki T. et al. Usefulness and limitations of endoscopic ultrasonography for detection of 96 lymph node metastasis in esophageal cancer. J. Gastroenterology 39(1): 90-91, 2004. 18. Miyazaki T. et al. Mucosa-associated lymphoid tissue lymphoma of the esophagus: case report 98 and review of the literature. Hepato-Gastroenterol. 51(57): 750-753, 2004. 19. Miyazaki T. et al. An immunohistochemical study of TIMP-3 expression in oesophageal 102 squamous cell carcinoma. Br. J. Cancer 91(8): 1556-1560, 2004. 20. Sohda M. et al. Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a 107 useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer. Int. J. Cancer 110(6): 838-844, 2004. 21. Sohda M. et al. The role of insulin-like growth factor 1 and insulin-like growth factor binding 114 protein 3 in human esophageal cancer. Anticancer Res. 24(5A): 3029-3034, 2004. 22. Faried A, et al. Expression of heat-shock protein Hsp60 correlated with the apoptotic index and 120 patient prognosis in human oesophageal squamous cell carcinoma. Eur. J. Cancer. 40(18): 23. Mochiki E. et al. Evaluation of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography 128 for gastric cancer. World J. Surg. 28(3): 247-253, 2004. 24. Mochiki E. et al. Postoperative functional evaluation of jejunal interposition with or without a 135 pouch after a total gastrectomy for gastric cancer. Am. J. Surg. 187(6): 728-735, 2004. 25. Nakabayashi T. et al. Arteriovenous malformation of the jejunum detected by arterial-phase 143 enhanced helical CT, a case report. Hepato-Gastroenterol. 51(58): 1066-1068, 2004. 26. Aihara R. et al. Mucin phenotypic expression in early signet ring cell carcinoma of the stomach: 146 its relationship with the clinicopathologic factors. Dig. Dis. Sci. 49(3): 417-424, 2004. 27. Garcia M. et al. Pranlukast, a leukotriene receptor antagonist, prolongs the duration of the 154 migrating motor complex in dogs. Dig. Dis. Sci. 49(7-8): 1228-1235, 2004. <Disease of the colon and rectum> (28 28. Asao T. et al. Laparoscopic surgery update for gastrointestinal malignancy. J. Gastroenterology 162 29. Kudo M. et al. Closed continuous hyperthermic peritoneal perfusion model in mice with 172 peritoneal dissemination of colon 26. Int. J. Hyperthermia 20(4): 441-450, 2004. 30. Takeuchi K. et al. Clinical studies of strangulating small bowel obstruction. Am. Surg. 70(1): 182 31. Takeuchi K. et al. Should patients over 85 years old be operated on for colorectal cancer? J. Clin. 187 Gastroenterol. 38(5): 408-413, 2004. 32. Takeuchi K. et al. Clinicopathological characteristics of poorly differentiated adenocarcinoma of 193 the colon and rectum. Hepato-Gastroenterol. 51(60): 1698-1702, 2004. 33. Morinaga N. et al. Laparoscopic transgastric tumor-everting resection of the gastric submucosal 198 tumor located near the esophagogastric junction. Surg. Laparosc. Endosc. Percutan. Tech. 14(6): 34. Tsutsumi S. et al. Autocrine motility factor signaling enhances pancreatic cancer metastasis. Clin. 203 Cancer Res. 10(22): 7775-7784, 2004. 35. Ide M. et al. Inactivation of 14-3-3sigma by hypermethylation is a rare event in colorectal cancers 213 and its expression may correlate with cell cycle maintenance at the invasion front. Cancer Letters 36. Tsuboi K. et al. Serum interleukin-12 and interleukin-18 levels as a tumor marker in patients with 222 esophageal carcinoma. Cancer Letters 205(2): 207-214, 2004. 37. Tsuboi K. et al. Liver metastases of a minute rectal carcinoid less than 5mm in diameter: a case 230 report. Hepato-Gastroenterol. 51(59): 1330-1332, 2004. <Disease of the liver, bile duct and pancreas> (38 38. Kojima T. et al. A localized primary sclerosing cholangitis preoperatively diagnosed as hilar 233 cholangiocarcinoma; report of a case. Hepato-Gastroenterol. 51(58): 961-963, 2004. 39. Shimura T. et al. Galectin-3, a novel binding partner of beta-catenin. Cancer Res. 64(18): 236 40. Kanoh K. et al. Antitumor effect of a splenic injection of 5-fluorouracil on metastatic liver cancer 241 in mice. J. Pharmacol Exp Ther. 308(1): 168-174, 2004. 41. Wada W. et al. The dependence of transforming growth factor-beta-induced collagen production 248 on autocrine factor activin A in hepatic stellate cells. Endocrinology. 145(6): 2753-2759, 2004. 42. Wada W. et al. Assessment of the function of the betaC-subunit of activin in cultured hepatocytes. 255 Am. J. Physiol Endocrinol Metab. 287(2): E247-254, 2004. 43. Saito T. et al. Expression of EphA2 and E-cadherin in colorectal cancer: correlation with cancer 263 metastasis. Oncol. Rep. 11(3): 605-611, 2004. 44. Yajima T. et al. Overexpression of Interleukin-15 increases susceptibility to 270 lipopolysaccharide- induced liver injury in mice primed with Mycobacterium bovis bacillus Calmette-Guerin. Infect. Immun. 72(7): 3855-3862, 2004. 45. Hashimoto S. et al. alpha(1)-Acid glycoprotein fucosylation as a marker of carcinoma progression 278 and prognosis. Cancer 101(12): 2825-2836, 2004. 46. Suehiro T. et al. Change in alpha glutathione s-transferase levels during liver resection. 290 Hepato-Gastroenterol. 51(60): 1747-1750, 2004. 47. Suehiro T. et al. Preoperative hyaluronic acid measurement to assess the hepatic functional 294 reserve. Hepato-Gastroenterol. 51(60): 1776-1779, 2004. 48. Suehiro T. et al. Accelerated rehabilitation with early postoperative oral feeding following 298 gastrectomy. Hepato-Gastroenterol. 51(60): 1852-1855, 2004. 49. Tani M. et al. Correlation between histone acetylation and expression of the MYO18B gene in 302 human lung cancer cells. Genes Chromosomes Cancer. 40(2): 146-151, 2004. 50. Tajima K. et al. Interferon-gamma differentially regulates susceptibility of lung cancer cells to 308 telomerase-specific cytotoxic T lymphocytes. Int. J. Cancer 110(3): 403-412, 2004. 51. Tajima K. et al. Identification of an epitope from the epithelial cell adhesion molecule eliciting 318 HLA-A*2402-restricted cytotoxic T- lymphocyte responses. Tissue Antigens. 64(6): 650-659, 52. Endoh H. et al. Prognostic model of pulmonary adenocarcinoma by expression profiling of eight 328 genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction. J. Clin. Oncol. 22(5): 811-819, 2004. 53. Yoshida T. et al. The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell 337 lung cancer. Ann. Oncol. 15(2): 252-256, 2004. 54. Kosaka T. et al. Mutations of the epidermal growth factor receptor gene in lung cancer: biological 342 and clinical implications. Cancer Res. 64(24): 8919-8923, 2004. 55. Uchida N, et al. A case of chondromatous tumor of the breast. Breast Cancer 11(2): 206-209, 347 56. Fujisawa T. et al. Functional localization of proprotein-convertase furin and its substrate TGFbeta 351 in EGF receptor-expressing gastric chief cells. Growth Factors. 22(1): 51-59, 2004. 57. Tabe Y. et al. Subcutaneous hemangioma of the breast: Report of a case Kitakanto Med. J. 54: 360 58. Takahashi A. et al. Evidence for segmental bile drainage by hepatic portoenterostomy for biliary 363 atresia: Cholangiographic, hepatic venographic, and histologic evaluation of the liver taken at liver transplantation. J. Pediatr. Surg. 39(1): 1-5, 2004. 59. Takahashi A. et al. Gastrointestinal manometric findings in a patient with total intestinal 368 aganglionosis. J. Pediatr. Surg. 39(7): 1104-1106, 2004. 60. Yamamoto H. et al. Infantile intestinal leiomyosarcoma is prognostically favorable despite histologic aggressiveness: case report and literature review. J Pediatr Surg. 39(8):1257-1260, 61. Takeuchi K. et al. A Modified Stapling Technique for Performing Billroth I Anastomosis after Distal Gastrectomy. World J. Surg. 62. Aihara R. et al. Clinical significance of mucin phenotype, beta-catenin and matrix metalloproteinase 7 in early undifferentiated gastric carcinoma. Br. J. Surg. These two papers will be presented in the next issue: Surgical Science 2005. We greatly thank following professors for supervising our researches; (Department of Diagnostic Radiology and Nuclear Medicine, Gunma University) (Department of Bacteriology & Infection Control, Gunma University Graduate school of Medicine) (Department of Pediatric Surgery, Dokkyo University School of Medicine, Koshigaya Hospital) (Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University) (Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University) (Department of Thoracic Surgery, Aichi Cancer Center Hospital) (Department of Tumor Pathology, Gunma University Graduate school of Medicine) (Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, School of (Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers) (Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institution of (Division of Immunology, Aichi Cancer Center Hospital) (Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma (Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Graduate school of Medicine and Dental Science, Niigata University) (Diagnostic Division, Otsuka Pharmaceutical Company) (Biology Division, National Cancer Center Research Institute) (Division of Host Defense, Medical Institute of Bioregulation, Kyushu University) Kuwano H., et al. Genetic alterations in esophageal cancer. Surg Today. Takahashi A, et al. Remission induced by interferon alfa in a patient with massive osteolysis and extension of lymph-hemangiomatosis: A severe case of Gorham-Stout Kato H, et al. The expression of RCAS1 in esophageal squamous cell carcinoma is associated with a poor prognosis. J Surg Oncol Kato H, et al. Endoscopic clips prevent self-expandable metallic stent migration. Kato H, et al. The incremental effect of positron emission tomography on diagnostic accuracy in the initial staging of esophageal carcinoma. Cancer Takeuchi K. et al. A modified stapling technique for performing billroth I anastomosis after distal gastrectomy. World J Surg Takeuchi K. et al. Drug resistance of Enterococcus faecium clinical isolates and the conjugative transfer of gentamicin and erythromycin resistance traits. FEMS Microbiol Tsukada K, et al. Clinical factors influencing CT findings in patients with acute Tsukada K, et al. Relationship between secretory leukocyte protease inhibitor levels in bronchoalveolar lavage fluid and postoperative pulmonary complications in patients with esopha geal cancer. Am J Surg Mochiki E, et al. Laparoscopy-assisted distal gastrectomy for early gastric cancer: Five Uchida N, et al. Schwannoma of the breast: report of a case. Surg Today Suehiro T, et al. The effect of the herbal medicines Dai-Kenchu-To and Keishi- Bukuryo-Gan on bowel movement after colorectal surgery. Hepato-Gastroenterol Suehiro T, et al. Hyperinsulinemia in the patients with colorectal cancer. Shimura T, et al. Efficacy of transplanting cryo-preserved and encapsulated xenogeneic fetal liver fragment as an auxiliary liver support in 90%- hepatectomized Shimura T, et al. Mucosa-associated lymphoid tissue lymphoma of the extrahepatic bile Shimura T, et al. Implication of galectin-3 in Wnt signaling.Cancer Res Haga N, et al. Esophageal manometric changes and gastroesophageal reflux symptoms after distal gastrectomy for gastric cancer. Hepato-Gastroenterol Tsutsumi S, et al. Loss of KAI1 expression in gastric cancer. Hepato-Gastroenterol Tsutsumi S, et al. Vascular Endothelial Growth Factor C (VEGF-C) Expression in pT2 Gastric Cancer Hepato-Gastroenterol Tsutsumi S, et al. Ets-1 Expression in Gastric Cancer Hepato-Gastroenterol Fukuchi M, et al. TGF-ß signaling in esophageal squamous cell carcinoma. Esophagus Aihara R. et al. Clinical significance of mucin phenotype, beta-catenin and matrix metalloproteinase 7 in early undifferentiated gastric carcinoma. Br J Surg Aihara R. et al. Incidence and distribution of hybrid goblet cells in complete type intestinal metaplasia of the stomach. Pathol Res Pract Fukai Y, et al. Correlation between laminin-5 ?2 chain and epidermal growth factor receptor expression in esophageal squamous cell carcinomas. Oncology Yajima T, et al. A novel role of IL-15 in early activation of memory CD8+ CTL after Wada S, et al. Rationale for nti-angiogenic cancer therapy with vaccination using epitope peptides erived from human vascular endothelial growth factor receptor 2 Faried A, et al. Correlation between RhoA overexpression and tumour progression in esophageal squamous cell carcinoma. Eur J Surg Oncol Kimura H, et al. Flat-type primary malignant melanoma of the esophagus treated by EMR : case report.Gastrointest Endosc Yamauchi H, et al. Bilateral ovarian teratomas successfully treated by ovary-conserving technique.-Report of a case- Pediatr Int Takita J, et al. Primary squamous cell carcinoma of the stomach: A case report with immunohistochemical and molecular biologic studies.Hepato-Gastroenterol AM J PHYSIOL-ENDOC M
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