Name :Nalidixic acid Cas No. :389-08-2 Synonyms:NOGRAM;NALIDIXIC ACID;NALADIXIC ACID;1,4-DIHYDRO-1-ETHYL-7-METHYL-1,8-NAPHTHYRIDIN-4-O NE-3-CARBOXYLIC ACID;1,4-DIHYDRO-1-ETHYL-7-METHYL-4-OXO-1,8-NAPHTHYRI DINE-3-CARBOXYLIC ACID;1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO-1,8-NAPHTHYRI DINE-3-CARBOXYLIC ACID;1-ETHYL-7-METHYL-1,8-NAPHTHYRIDINE-4-ONE-3-CARBO XYLIC ACID;1,8-Naphthyridine-3-carboxylicacid,1-ethyl-1,4-dihydro-7-m ethyl-4-oxo- Molecular Formula:C12H12N2O3 Molecular Weight:232.24 Wiki: Nalidixic acid Systematic (IUPAC) name 1-Ethyl-7-methyl-4-oxo-[1,8]naphthyridine-3-carboxylic acid Clinical data AHFS/Drugs.com Consumer Drug Information Pregnancy cat. B U.S. Legal status Not FDA approved for clinical use in the United States Routes Oral Pharmacokinetic data Protein binding 90% Metabolism Partially Hepatic Half-life 6-7 hours, significantly longer in renal impairment Identifiers CAS number 389-08-2Â Y ATC code J01 MB02 PubChem CID 4421 DrugBank DB00779 ChemSpider 4268Â Y UNII 3B91HWA56MÂ Y KEGG D00183Â Y ChEBI CHEBI:100147Â Y ChEMBL CHEMBL5Â Y Chemical data Formula C12H12N2O3Â Mol. mass 232.235 g/mol SMILES O=C\2c1c(nc(cc1)C)N(/C=C/2C(=O)O)CC InChI InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11 (8)14/h4-6H,3H2,1-2H3,(H,16,17)Â Y Key:MHWLWQUZZRMNGJ-UHFFFAOYSA-NÂ Y Â YÂ (what is this?)Â Â (verify) Nalidixic acid (tradenames Nevigramon, Neggram , Wintomylon and WIN 18,320) is the first of the synthetic quinolone antibiotics. In the technical sense, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom.[1] Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s.[1] Used clinically from 1967.[1] Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. It has historically been used for treating urinary tract infections, caused, for example, by Escherichia coli, Proteus, Shigella, Enterobacter, and Klebsiella. It is no longer clinically used for this indication in the USA as less toxic and more effective agents are available. It is also a tool in studies as a regulation of bacterial division. It selectively and reversibly blocks DNA replication in susceptible bacteria. Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and topoisomerase IV and induce formation of cleavage complexes.[2] It also inhibits the nicking-closing activity on the subunit of DNA gyrase that releases the positive binding stress on
the supercoiled DNA. Get more Information about CAS No. .
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Jordan S. Josephson, MD triamtene (Dyazide) and hydro- Manhattan Eye, Ear and Throat Hospital chlorothiazide (HydroDIURIL)—tohelp the kidneys excrete excessfluids. This can help prevent fur-ther attacks of Ménière’s disease. ENVIRONMENTAL TOXINS mental toxins, but certain peoplemay have a sensitivity that causesOften-overlooked triggers can make you suffer needlessly. (ca
Name :Nalidixic acid