Pablo Perel Personal Particulars Birth date: November 4, 1967 Nationality: Argentine Professional Experience:
2011-present: Coordinator Centre for Global Non Communicable Diseases, London School of Hygiene & Tropical Medicine. 2011-present: Senior Clinical Lecturer, Nutrition and Population Health Intervention Research Department, Epidemiology and Population Health Faculty, London School of Hygiene & Tropical Medicine. 2007-2011: Clinical Lecturer, Nutrition and Population Health Intervention Research Department, Epidemiology and Population Health Faculty, London School of Hygiene & Tropical Medicine.
2005-2007: Research Fellow, Nutrition and Population Health Intervention Research Department, Epidemiology and Population Health Faculty, London School of Hygiene & Tropical Medicine. 2000-2003: Epidemiologist Consultant, United Nations Program, Vigia Program, Health Ministry, Buenos Aires, Argentina.
1998-1999 Chief of Cardiology Fellows (Hospital de Clínicas de Buenos Aires, Argentina)
1992-1995: Residence in Internal Medicine (Hospital Español, Buenos Aires, Argentina) Graduate studies Medical Doctor (Universidad de Buenos Aires, Argentina) Honour degree (Equivalent to First Class) Year of graduation: 1991 Postgraduate studies 2005-2009-: PhD in Clinical Epidemiology (London School of Hygiene and Tropical Medicine, London United Kingdom) 2003-2004: Masters of Epidemiology (London School of Hygiene and Tropical Medicine, London United Kingdom) Pass with distinction 1996-1998: Cardiologist specialist (Universidad de Buenos Aires, Argentina.) Final Mark: 10/10 (Equivalent to First Class) Selected publications (only last 5 years) Perel P, Prieto-Merino D, Shakur H, Clayton T, Lecky F, Bouamra O, Russell R, Faulkner M, Steyerberg E W, Roberts I. Predicting early death in patients with traumatic bleeding: development and validation of a prognostic model. BMJ 2012 (accepted).
Dewan Y, Komolafe EO, Mejía-Mantilla JH, Perel P, Roberts I, Shakur H.Trials. 2012; 13(1):87.
Ker K, Edwards P, Perel P, Shakur H, Roberts I.BMJ. 2012; 344:e3054.
Ker K, Kiriya J, Perel P, Edwards P, Shakur H, Roberts I. Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic review and data from the CRASH-2 trial. BMC Emer Med 2012; (12):3
Holmes MV, Perel P, Shah T, Hingorani AD, Casas JP. Improvements in pharmacogenetic studies are needed for translation into clinical practice: the case of CYP2C19 genotype and clopidogrel response. JAMA. 2011; 306:2704-14.
Turner E L, Perel P, Clayton T, Edwards P, Hernández A, Roberts I, Shakur H, Steyerberg E. Covariate adjustment increases power in randomized controlled trials: an example in traumatic brain injury. JCE. 2011 (Epub ahead of print) Perel P, Al-Shahi Salman R, Constain A , Dewan Y , Herrera J, Kawahara T, Lal AP, Mejía-Mantilla J, Morales C, Morris Z, Prieto-Merino D , Ramana PV, Ravi RR, Roberts I, Sandercock P, Shakur H, Wardlaw J (CRASH-2 IBS Collaborators) Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study).2011;343:d3795. doi: 10.1136/bmj.d3795.
Roozenbeek B, Lingsma H, Perel P, Edwards P, Roberts I, Murray G, Maas A, Steyerberg E. The added value of ordinal analysis in clinical trials: an example in traumatic brain injury. Crit Care. 2011;15(3):R127.
Guerriero C, Cairns J, Perel P, Shakur H, Roberts I. Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. PloS One 2011;6(5):e18987
Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377(9771):1096-101, 1101.e1- 2.
Ferrante D, Apro N, Ferreira V, Virgolini M, Aguilar V, Sosa M, Perel P, Casas J. Feasibility of salt reduction in processed foods in Argentina.2011;29(2):69-75.
Rehn M, Perel P, Blackhall K, Lossius HM. Prognostic models for the early care of trauma patients: a systematic review. Scand J Trauma Resusc Emerg Med. 2011;19:17.
Shakur H, Roberts R, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010; 376(9734):23-32. .
Guerriero C, Cairns J, Jayaraman S, Roberts I, Perel P, Shakur H.Cost Eff Resour Alloc. 2010 ;8(1):1. Perel P, Roberts I, Bouamra O, Woodford M, Mooney J, Lecky F. Intracranial bleeding in patients with traumatic brain injury: a prognostic study. BMC Emerg Med. 2009 Aug 3;9:15.
Bautista LE, Casas JP, Herrera VM, Miranda JJ, Perel P, Pichardo R, González A, Sanchez JR, Ferreccio C, Aguilera X, Silva E, Oróstegui M, Gómez LF, Chirinos JA, Medina-Lezama J, Pérez CM, Suárez E, Ortiz AP, Rosero L, Schapochnik N, Ortiz Z, Ferrante D; Latin-American Consortium of Studies in Obesity (LASO)Obes Rev. 2009 May;10(3):364- 70.
Herrera VM, Casas JP, Miranda JJ, Perel P, Pichardo R, González A, Sanchez JR, Ferreccio C, Aguilera X, Silva E, Oróstegui M, Gómez LF, Chirinos JA, Medina- Lezama J, Pérez CM, Suárez E, Ortiz AP, Rosero L, Schapochnik N, Ortiz Z, Ferrante D, Diaz M, Bautista LE. Interethnic differences in the accuracy of anthropometric indicators of obesity in screening for high risk of coronary heart disease Int J Obes (Lond). 2009 Feb 24
De Silva MJ, Roberts I, Perel P, Edwards P, Kenward MG, Fernandes J, Shakur H, Patel V; on behalf of the CRASH Trial Collaborators. Patient outcome after traumatic brain injury in high-, middle- and low-income countries: analysis of data on 8927 patients in 46 countries. Int J Epidemiol. 2008 Sep 9. [Epub ahead of print]
How effective are some common treatments for traumatic brain injury?2008 Aug 14;337:a865. doi: 10.1136/bmj.a865
Habbema JD,Predicting outcome after traumatic
brain injury: development and international validation of prognostic scores based on admission characteristics.2008 Aug 5;5(8):e165
Perel PRelation between the global burden of disease and randomized clinical trials conducted in Latin America published in the five leading medical journals2008 Feb 27;3(2):e1696. Perel P, Arango M, Clayton T, Edwards P, Komolafe E, Poccock S, Roberts I, Shakur H, Steyerberg E, Yutthakasemsunt S. Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients BMJ. 2008 Feb 23;336(7641):425-9. Epub 2008 Feb 12. Editorial membership in Medical Journals Editor Cochrane Heart Group 2012 Associate Editor Trials Journal 2012 Associate Editor BMC Medical Research Methodology 2011-present Editor Cochrane Injuries Group 2005-present Main teaching Experience:
Course Organizer Reporting and Reviewing Clinical Trials Master in Clinical Trials LSHTM 2011- present Course Organizer Systematic Reviews and Meta-Analyses of Health Research LSHTM 2010- present Course Organizer Non-Communicable Epidemiology, Master of Epidemiology by Distance Learning London School of Hygiene & Tropical Medicine 2005-2009 Selected grants
Principal investigator Health Technology Assessment (HTA): Development and validation of a risk score for trauma patients with haemorrhage The CRASH-2 score Total amount: £140,022 (1/10/2010 to 31/03/2012) Co-applicant Medical Research Council: Partnership Grant for Prognostic Research A Strategic Initiative in Translational Pathways (PI at LSHTM) Total amount £807,318 (1/01/2012 to 31/12/2014)
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