Tadalafil entfaltet seine Wirkung über eine selektive Hemmung der PDE5, wodurch die Konzentration von cGMP im glatten Muskelgewebe stabil bleibt. Diese biochemische Modulation resultiert in einer langanhaltenden Relaxation der Gefäßwände. Der Wirkstoff wird nach oraler Einnahme effizient resorbiert, mit einer Bioverfügbarkeit von rund 80 %. Seine Halbwertszeit von bis zu 36 Stunden ist innerhalb dieser Substanzklasse außergewöhnlich. Abgebaut wird er in der Leber, hauptsächlich durch CYP3A4, mit anschließender biliärer Exkretion. Typische unerwünschte Wirkungen entstehen durch eine verstärkte Vasodilatation, etwa Kopfschmerzen oder Flush. Pharmakologisch wird cialis generika vor allem durch die verlängerte Wirkungsdauer charakterisiert.

Homotoxicology.net

EP_Vertigo_060803 03.09.2003 10:49 Uhr Seite 2 An Unsurpassed
Product Profile
Vertigoheel
Histamine
Antihistamines
Analogues
(i.e.: Dimen-
(i.e.: Betahistine)
hydrinate)
Prevalence of Vertigo
The symptom of vertigo is very frequent in every popula- tion. In general 20% of men and even 40% of womencomplain about vertigo attacks. The treatment of vertigo remains still very difficult, as ver- tigo can be caused by various vascular, cardio-vascular, metabolic, traumatic or degenerative disturbances.
Vertigoheel offers a broad symptomatic treatment with- out any known side-effects or contraindications.
Demonstrated Efficacy
Clinical studies provide proof that
Vertigoheel significantly reduces
the severity of vertigo-specific
symptoms and improves the quality
of life for vertigo patients.1,5)
EP_Vertigo_060803 03.09.2003 10:49 Uhr Seite 3 Vertigoheel®
Study of Vertigoheel
Study of Vertigoheel
vs. Dimenhydrinate5)
vs. Betahistine1)
Intensity of vertigo attacks
Frequency of vertigo attacks
Vertigoheel (n= 352)
Vertigoheel (n= 53)
Dimenhydrinate (n= 422)
Betahistine (n= 52)
Start of treatment
End of treatment
Duration of vertigo attacks
Intensity of vertigo attacks
Vertigoheel (n= 352)
0 = no discomfort
Dimenhydrinate (n= 422)
1 = slight discomfort
2 = moderate discomfort
3 = severe discomfort
Start of treatment
End of treatment
EP_Vertigo_060803 03.09.2003 10:49 Uhr Seite 4 Vertigoheel®
Therapy
Recommendations
Non-drowsy formula
Acute therapy
Maintenance therapy
No contraindications or
restrictions with regard
to age or duration of therapy
No interactions with
other drugs (suitable
for long-term treatment)
Vertigoheel® Drops, Tablets, Injection Solution
References:
Composition: Drops: 100 g cont.: Anamirta cocculus D4 70 g; Conium maculatum D3,
1) Weiser M, Strösser W, Klein P. Homeopathic vs Conventional Treatment of Ambra grisea D6, Petroleum rectificatum D8 10 g each. Contains 35 vol.-% alcohol Tablets:
Vertigo - A randomized Double-blind Controlled Clinical Study. Arch 1 tablet cont.: Anamirta cocculus D4 210 mg; Conium maculatum D3, Ambra grisea D6, Otolaryngol Head Neck Surg 1998, 124: 879-885 Petroleum rectificatum D8 30 mg each. Injection solution: 1.1 ml cont.: Anamirta cocculus
2) Canty P, Vlentine J, Papworth SJ. Betahistine in Peripheral Vertigo: D3 7.7µl; Conium maculatum D2, Ambra grisea D5, Petroleum rectificatum D7 1.1 µl each.
A Double-Blind, Placebo-Controlled, Cross-Over Study of Serc® versus Indications: Dizziness of various origins (particularly arising from arteriosclerosis).
Placebo. J Laryngol Otol. 1981, 95: 687-692 Contraindications: None known. Side effects: None known. Interactions with other
medication: None known. Note: Vertigoheel is not incompatible with alcohol and has no
3) Oosterveld WJ. Betahistine Dihydrochloride in the Treatment of Vertigo of sedative properties (does not influence safety in traffic, etc.). Dosage: Drops: In general, 15-
Peripheral Vestibular Origin: A Double-Blind Placebo-Controlled Study.
20 drops 3 times daily; in sporadic dizziness and nausea initially 10 drops every 15 minutes.
Tablets: In general, 3 tablets to be dissolved in the mouth 3 times daily; in sporadic dizziness
4) Mulch G. Comparison of the Effectiveness of Antivertiginous Drugs by and nausea initially 1 tablet every 15 minutes. Injection solution: In sporadic dizziness and
Double-Blind Procedure. The Effect of Diazepam, Dimenhydrinate and nausea daily, otherwise 3-1 times weekly 1 ampoule i.m., s.c., i.d., i.v. Package sizes:
Sulpirid on the Human Vestibular Spontaneous Nystagmus. Laryngologie, Drops: Drop bottles containing 30 and 100 ml. Tablets: Packs containing 50 and 250 tablets.
Rhinologie, Otologie, 1976, 55 (5): 392-399 Injection solution: Packs containing 10, 50, and 100 ampoules of 1.1 ml.
5) Wölschner U, Strösser W, Weiser M, Klein P. Treating Vertigo - Homeopathic Combination Remedy Therapeutically Equivalent to Dimenhydrinate.
Biologische Medizin 2001, Vol 30 No. 4: 184-90 EP_Vertigo_060803 03.09.2003 10:50 Uhr Seite 5 Vertigoheel®
T h e M o d e r n H o m o e o p a t h i c
T h e r a p y f o r
Dizziness
Biologische Heilmittel Heel GmbHBaden-Baden, Germanywww.heel.com 20483 08/03 Ga 2003 by Biologische Heilmittel Heel GmbH

Source: http://www.homotoxicology.net/Documents/Brochures/Vertigoheel.pdf