NEWS & VIEWS The Protective Side of the Mineralocorticoid Receptor Celso E. Gomez-Sanchez and Elise P. Gomez-Sanchez (For article see page 1330) Infertility in the Southern White Rhino: Is Diet the Source of the Problem? Heather B. Patisaul (For article see page 1444) The Placenta, a Transducer Linking Maternal Nutrition to Adult Disease in the Offspring? Roger Smith and Kaushik Maiti (For article see page 1464) Primary Aldosteronism Takes (KCNJ)Five! Maria-Christina Zennaro (For article see page 1774) Tacking Toward Reconciliation on Tacr3/TACR3 Mutations Robert A. Steiner and Víctor M. Navarro (For article see page 1498) Lipocalin 2: A “Sexy” Adipokine that Regulates 17-Estradiol and Obesity Susan K. Fried and Andrew S. Greenberg (For article see page 1183) MINIREVIEWS Minireview: Animal Models and Mechanisms of Ovarian Cancer Development Lisa K. Mullany and JoAnne S. Richards Minireview: Human Ovarian Cancer: Biology, Current Management, and Paths to Personalizing Therapy Ignacio Romero and Robert C. Bast, Jr. BRIEF REPORT Postnatal Aromatase Blockade Increases c-fos mRNA Responses to Acute Restraint Stress in Adult Male Rats Brenda Bingham, Nancy X. R. Wang, Leyla Innala, and Victor Viau CALCIUM-REGULATING HORMONES Intestinal Cell Phosphate Uptake and the Targeted Knockout of the 1,25D -MARRS Receptor/PDIA3/ERp57 Ilka Nemere, Natalio Garcia-Garbi, Günter J. Hämmerling, and Quinton Winger ENDOCRINOLOGY (Print ISSN 0013-7227; Online ISSN 1945-7170; USPS 176-100) is the official journal of The Endocrine Society, published monthlyby The Endocrine Society, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817. Periodicals postage paid at Chevy Chase, MD, and atadditional mailing offices. Printed in the USA. POSTMASTER: Send address changes to Endocrinology, 8401 Connecticut Avenue, Suite 900, ChevyChase, MD 20815-5817. Printed on acid-free paper. Table of Contents and abstracts for each issue available on the issue mail date at http://endo.endojournals.org. 2011 Subscription information is located on the Author and Subscription Information page. Copyright 2012 by The EndocrineSociety. Conditional Inactivation of Noggin in the Postnatal Skeleton Causes Osteopenia Ernesto Canalis, Lisa J. Brunet, Kristen Parker, and Stefano Zanotti Dual-Specificity Phosphatases Are Implicated in Severe Hyperplasia and Lack of Response to FGF23 of Uremic Parathyroid Glands from Rats Pablo Román-García, Natalia Carrillo-López, Manuel Naves-Díaz, Isabel Rodríguez, Alberto Ortiz, and Jorge B. Cannata-Andía CANCER-ONCOGENES Wild-Type Tumor Repressor Protein 53 (TRP53) Promotes Ovarian Cancer Cell Survival Lisa K. Mullany, Zhilin Liu, Erin R. King, Kwong-Kwok Wong, and JoAnne S. Richards DIABETES-INSULIN-GLUCAGON-GASTROINTESTINAL Regulation of Glucose Transport by ROCK1 Differs from That of ROCK2 and Is Controlled by Actin Polymerization Kwang-Hoon Chun, Kazushi Araki, Yuna Jee, Dae-Ho Lee, Byung-Chul Oh, Hu Huang, Kyong Soo Park, Sam W. Lee, Janice M. Zabolotny, and Young-Bum Kim Functional and Structural Adaptations in the Pancreatic ␣-Cell and Changes in Glucagon Signaling During Protein Malnutrition Laura Marroquí, Thiago M. Batista, Alejandro Gonzalez, Elaine Vieira, Alex Rafacho, Simone J. Colleta, Sebastião R. Taboga, Antonio C. Boschero, Angel Nadal, Everardo M. Carneiro, and Ivan Quesada Accumulation of Intrahepatic Islet Amyloid in a Nonhuman Primate Transplant Model Chengyang Liu, Brigitte Koeberlein, Michael D. Feldman, Rebecca Mueller, Zhonglin Wang, Yanjing Li, Kristin Lane, Clifford C. Hoyt, John E. Tomaszewski, Ali Naji, and Michael R. Rickels Angiotensin Receptor Blockade Increases Pancreatic Insulin Secretion and Decreases Glucose Intolerance during Glucose Supplementation in a Model of Metabolic Syndrome Ruben Rodriguez, Jose A. Viscarra, Jacqueline N. Minas, Daisuke Nakano, Akira Nishiyama, and Rudy M. Ortiz ENERGY BALANCE-OBESITY Body Weight Impact on Puberty: Effects of High-Calorie Diet on Puberty Onset in Female Rhesus Monkeys Ei Terasawa, Joseph R. Kurian, Kim L. Keen, Nicholas A. Shiel, Ricki J. Colman, and Saverio V. Capuano Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1؊/؊ Mice Fen Xu, David Burk, Zhanguo Gao, Jun Yin, Xia Zhang, Jianping Weng, and Jianping Ye GENERAL ENDOCRINOLOGY Expression of Chemokine CXCL12 and Its Receptor CXCR4 in Folliculostellate (FS) Cells of the Rat Anterior Pituitary Gland: The CXCL12/CXCR4 Axis Induces Interconnection of FS Cells Kotaro Horiguchi, Cimi Ilmiawati, Ken Fujiwara, Takehiro Tsukada, Motoshi Kikuchi, and Takashi Yashiro Estradiol Release Kinetics Determine Tissue Response in Ovariectomized Rats Christiane Otto, Ingrid Kantner, Reinhard Nubbemeyer, Jenny Schkoldow, Iris Fuchs, Elisabeth Krahl, Richardus Vonk, Christiane Schüler, Karl-Heinrich Fritzemeier, and Reinhold G. Erben Proadrenomedullin N-Terminal 20 Peptide Increases Kinesin’s Velocity Both in Vitro and in Vivo Ignacio M. Larráyoz and Alfredo Martínez The Mitochondrial Citrate Carrier (CIC) Is Present and Regulates Insulin Secretion by Human Male Gamete Anna R. Cappello, Carmela Guido, Antonella Santoro, Marta Santoro, Loredana Capobianco, Daniela Montanaro, Marianna Madeo, Sebastiano Andò, Vincenza Dolce, and Saveria Aquila Transcriptome Analysis Reveals Differentially Expressed Transcripts in Rat Adrenal Zona Glomerulosa and Zona Fasciculata Koshiro Nishimoto, Christine S. Rigsby, Tao Wang, Kuniaki Mukai, Celso E. Gomez-Sanchez, William E. Rainey, and Tsugio Seki GLUCOCORTICOIDS-CRH-ACTH-ADRENAL The Development of Hypertension and Hyperaldosteronism in a Rodent Model of Life-Long Obesity Carrie A. Northcott, Greg D. Fink, Hannah Garver, Joseph R. Haywood, Erinn L. Laimon-Thomson, Jonathon L. McClain, Paulo W. Pires, William E. Rainey, Christine S. Rigsby, and Anne M. Dorrance Potassium Channel Mutant KCNJ5 T158A Expression in HAC-15 Cells Increases Aldosterone Synthesis Kenji Oki, Maria W. Plonczynski, Milay Luis Lam, Elise P. Gomez-Sanchez, and Celso E. Gomez-Sanchez (For editorial see page 1575) Glucocorticoids Enhance Intestinal Glucose Uptake Via the Dimerized Glucocorticoid Receptor in Enterocytes Sybille D. Reichardt, Michael Föller, Rexhep Rexhepaj, Ganesh Pathare, Kerstin Minnich, Jan P. Tuckermann, Florian Lang, and Holger M. Reichardt GROWTH FACTORS-CYTOKINES Long-Term Fgf23 Deficiency Does Not Influence Aging, Glucose Homeostasis, or Fat Metabolism in Mice with a Nonfunctioning Vitamin D Receptor Carmen Streicher, Ute Zeitz, Olena Andrukhova, Anne Rupprecht, Elena Pohl, Tobias E. Larsson, Wilhelm Windisch, Beate Lanske, and Reinhold G. Erben Chronic Inhibition of ERK1/2 Signaling Improves Disordered Bone and Mineral Metabolism in Hypophosphatemic (Hyp) Mice Martin Y. H. Zhang, Daniel Ranch, Renata C. Pereira, Harvey J. Armbrecht, Anthony A. Portale, and Farzana Perwad NEUROENDOCRINOLOGY Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response Wenying Quan, Hyun-Kyong Kim, Eun-Yi Moon, Su Sung Kim, Cheol Soo Choi, Masaaki Komatsu, Yeon Taek Jeong, Moon-Kyu Lee, Kwang-Won Kim, Min-Seon Kim, and Myung-Shik Lee Development, Sex Steroid Regulation, and Phenotypic Characterization of RFamide-Related Peptide (Rfrp) Gene Expression and RFamide Receptors in the Mouse Hypothalamus Matthew C. Poling, Joshua Kim, Sangeeta Dhamija, and Alexander S. Kauffman Evidence for Differential Regulation of GnRH Signaling via Heterodimerization among GnRH Receptor Paralogs in the Protochordate, Ciona intestinalis Tsubasa Sakai, Masato Aoyama, Tsuyoshi Kawada, Takehiro Kusakabe, Motoyuki Tsuda, and Honoo Satake Direct Interactions between Calcitonin-Like Receptor (CLR) and CGRP-Receptor Component Protein (RCP) Regulate CGRP Receptor Signaling Sophie C. Egea and Ian M. Dickerson Identification of the Receptors for Prolactin-Releasing Peptide (PrRP) and Carassius RFamide Peptide (C-RFa) in Chickens Yajun Wang, Crystal Ying Wang, Yuting Wu, Guian Huang, Juan Li, and Frederick C. Leung Assessment of Epigenetic Contributions to Sexually-Dimorphic Kiss1 Expression in the Anteroventral Periventricular Nucleus of Mice Sheila J. Semaan, Sangeeta Dhamija, Joshua Kim, Eric C. Ku, and Alexander S. Kauffman Developmental Increase in Kisspeptin-54 Release in Vivo Is Independent of the Pubertal Increase in Estradiol in Female Rhesus Monkeys (Macaca mulatta) Kathryn A. Guerriero, Kim L. Keen, and Ei Terasawa Sexual Dimorphism of Growth Hormone in the Hypothalamus: Regulation by Estradiol Melisande L. Addison and Emilie F. Rissman Recurrent Hypoglycemia Is Associated with Loss of Activation in Rat Brain Cingulate Cortex Paul Hurst, Alastair S. Garfield, Claire Marrow, Lora K. Heisler, and Mark L. Evans RENAL-CARDIAC-VASCULAR Estrogenic Action on Arterial Smooth Muscle: Permissive for Maintenance of CRHR2 Expression Shan Wang, Xiaoyan Zhu, Binhai Cong, Xingji You, Yangkai Wang, Weizhong Wang, and Xin Ni REPRODUCTION-DEVELOPMENT Hematopoetic Prostaglandin D Synthase: An ESR1-Dependent Oviductal Epithelial Cell Synthase Phillip J. Bridges, Myoungkun Jeoung, Sarah Shim, Ji Yeon Park, Jae Eun Lee, Lindsay A. Sapsford, Kourtney Trudgen, Chemyong Ko, Myung Chan Gye, and Misung Jo Perinatal Programming of Adult Rat Germ Cell Death After Exposure to Xenoestrogens: Role of microRNA miR-29 Family in the Down-Regulation of DNA Methyltransferases and Mcl-1 Léo Meunier, Bénazir Siddeek, Aurélie Vega, Nadjem Lakhdari, Lilia Inoubli, Rachel Paul Bellon, Géraldine Lemaire, Claire Mauduit, and Mohamed Benahmed Excess DAX1 Leads to XY Ovotesticular Disorder of Sex Development (DSD) in Mice by Inhibiting Steroidogenic Factor-1 (SF1) Activation of the Testis Enhancer of SRY-box-9 (Sox9) Louisa M. Ludbrook, Pascal Bernard, Stefan Bagheri-Fam, Janelle Ryan, Ryohei Sekido, Dagmar Wilhelm, Robin Lovell-Badge, and Vincent R. Harley Cellular Distribution, Regulated Expression, and Functional Role of the Anorexigenic Peptide, NUCB2/Nesfatin-1, in the Testis D. García-Galiano, R. Pineda, T. Ilhan, J. M. Castellano, F. Ruiz-Pino, M. A. Sánchez-Garrido, M. J. Vazquez, S. Sangiao-Alvarellos, A. Romero-Ruiz, L. Pinilla, C. Diéguez, F. Gaytán, and M. Tena-Sempere Inhibition of Delta-Like Ligand 4 Induces Luteal Hypervascularization Followed by Functional and Structural Luteolysis in the Primate Ovary Hamish M. Fraser, Julie M. Hastings, Deborah Allan, Keith D. Morris, John S. Rudge, and Stanley J. Wiegand Live Imaging Reveals the Link Between Decreased Glucose Uptake in Ovarian Cumulus Cells and Impaired Oocyte Quality in Female Diabetic Mice Qiang Wang, Maggie M. Chi, and Kelle H. Moley The Involvement of Neurofilament Heavy Chain Phosphorylation in the Maturation and Degeneration of Rat Oocytes Noriyuki Takahashi and Bunpei Ishizuka RNA-seq Analysis of the Functional Compartments within the Rat Placentation Site Kartik Shankar, Ying Zhong, Ping Kang, Michael L. Blackburn, Michael J. Soares, Thomas M. Badger, and Horacio Gomez-Acevedo Cortisol Induces Aromatase Expression in Human Placental Syncytiotrophoblasts Through the cAMP/Sp1 Pathway Wangsheng Wang, Jianneng Li, Yuchun Ge, Wenjiao Li, Qun Shu, Haiyan Guan, Kaiping Yang, Leslie Myatt, and Kang Sun FOXL2 Is Involved in the Synergy between Activin and Progestins on the Follicle-Stimulating Hormone -Subunit Promoter Yasmin Ghochani, Jasjit K. Saini, Pamela L. Mellon, and Varykina G. Thackray THYROID-TRH-TSH Adoptive Transfer of Antithyrotropin Receptor (TSHR) Autoimmunity from TSHR Knockout Mice to Athymic Nude Mice Mami Nakahara, Kristian Johnson, Anja Eckstein, Ryo Taguchi, Masanobu Yamada, Norio Abiru, Yuji Nagayama TRANSLATIONAL HIGHLIGHTS THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ABSTRACTS
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Subcellular visualization of Rho-kinase (ROCK) isoforms in L6 myoblasts is shown using fluorescent immunohistochemistry (ROCK1, left panels; ROCK2,right panels). Top: ROCK1 (red) was localized in the perinuclear region while ROCK2 (red) was distributed evenly in the cytoplasm. Nuclei werecounterstained with 4Ј,6-diamidino-2-phenylindole (DAPI, blue) and microtubules visualized with -tubulin specific antibodies (green). Bottom half,center images: Partial colocalization of ROCK isoforms (red) was observed with cytochrome C IV (middle, green), a mitochondrial marker, and Rab5(bottom, green), a endosomal marker, as visualized by fluorescent immunohistochemistry. Higher magnification images are shown adjacent (left orright) to each respective image. Scale bar, 20 m. From article in this issue by Chun et al., pages 1649 –1662.
MF. Ramón Rosa, S. Ballesteros, R. Martínez-Arrieta Servicio de Información Toxicológica. Instituto Nacional de Toxicología y Ciencias Forenses. Rev Pediatr Aten Primaria. 2006;8:439-52 Mª Fátima Ramón Rosa, f.ramon@mju.es Resumen Cada vez es más frecuente el uso de neurolépticos en la infancia y adolescencia, y las in- toxicaciones por estos fármacos no son despreciab
Whole-Body Cryotherapy in Atopic DermatitisAtopic dermatitis (AD) is a chronic inflammatory skin disease with dry and itchy skin causing remarkable adverse impact on quality of life. Some patients do not tolerate treatments, or in some cases the treatments are ineffective. Effective combination therapies for moderate or severe AD are lacking or scarce. Very cold air has been reported to increase